Antiviral Therapy for HIV Infection

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Author:
jtmercado2005
ID:
36618
Filename:
Antiviral Therapy for HIV Infection
Updated:
2010-09-22 15:50:40
Tags:
HIV
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Description:
HIV flash cards
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The flashcards below were created by user jtmercado2005 on FreezingBlue Flashcards. What would you like to do?


  1. Highly Active Antiretroviral Therapy (HAART)
    • - HIV as a chronic disease
    • - Patient remains infectious
    • - Requires three or four drugs to suppress virus and prevent resistant strains
    • - compliance issues
    • - goal is to suppress viral load to undetectable (below where lab can detect it)
    • - requires management in HIV specialty clinic
  2. Nuceloside Reverse Transcriptase Inhibitors (NRTIs)
    • - suppress synthesis of viral DNA
    • - risk of lactic acidosis and hepatomegaly (symptoms include nausea, vomiting, abdominal pain, malaise, hyperventilation
  3. Zidovudine (Retrovir)(AZT)
    • (NRTI)
    • - can cause anemia and neutropenia requiring erythropoietin, granlocyte colony-stimulating factors
    • - monitor CBC
  4. Didanosine (Videx)(DDI)
    • (NRTI)
    • - risk of pancreatitis, peripheral neuropathy
  5. Abacavir (Ziagen)
    - severe hypersensitivity reactions
  6. Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
    • - Nevirapine (Viramune)
    • - risk of rash (can evolve into Stevens-Johnson Syndrom)
    • - Risk of hepatotoxicity (monitor ALT, AST, risk increased in chronic hepatitis pt)
    • - induce CYP 450 Enzymes (reduces level of oral contraceptives, protease inhibitors)
  7. Protease Inhibitors
    • Indinavir (Crixivan)
    • - metabolic effects: hyperglycemia, fat redistribution, hyperlipidemia, osteoporosis
    • - GI upset
    • - CYP 450 Interactions:
    • - levels increased by ketoconazole, clarithromycin, grapefruit juice
    • - levels decreased by rifampin, phenytoin, carbamazipine, St Johns Wort

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