Vickroy Pharm drugs-ans

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Author:
catkang
ID:
37068
Filename:
Vickroy Pharm drugs-ans
Updated:
2010-09-25 12:48:10
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pharmacology vickroy
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ans drugs
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  1. Acetylcholine-actions and side effects
    • muscarinic and nicotinic agonist (para and symp)
    • side effects:
    • Vasodilation, bradycardia, ↑ contractility, cramping, nausea, vomiting, defecation, urinary incontinence, bronchoconstriction,
    • ↑ mucus secretion, CNS excitation
  2. Bethanocol actions
    indications
    contraindications
    OD Tx
    • Muscarinic agonist-cardiovasc. inhib
    • feline bladder atony
    • GI/urinary obstruction, questionable GI or UG wall integrity
    • atropine
  3. Epinephrine-actions
    indications
    • mixed alpha and beta agonist
    • anaphylactic shock, cardiopulmonary arrest, with local anesthetic for vasoconstriction, bronchiole dilation, reverse hypotension/maintain BP
  4. Epinephrine contraindications
    OD Tx
    • CHF, hypovolemic shock, hyperthyroidism, coronary dz, DO NOT GIVE TO ANIMALS THAT HAVE HAD ACEPROMAZINE
    • alpha blocker (phentolamine); beta blocker (propanolol)
  5. Norepinephrine-actions
    indications
    contraindications
    • Mixed alpha and beta 1 agonist
    • maintain BP during acture hypotensive crisis
    • shock, hypertension, hyperthyroidism, arteriosclerosis, coronary dz, nephritis
  6. Prazosin-action
    indications
    contraindications
    • alpha 1 antagonist
    • vasodilation, urethral obstruction
    • hypovolemic shock
  7. xylazine-actions
    indications
    metabolism
    • alpha 2 agonist
    • sedative/analgesic (esp horses-CNS effects) emetic (esp cats)
    • liver
  8. Xylazine-contraindications
    side effects
    OD Tx
    • ventricular arrhythmias, seizures, foals, pregnant
    • catecholamine-induced dysarrhythmias, depression of swallowing and gastric secretions, decrease BP=AV block
    • Yohimbine
  9. Atenolol-actions
    indications
    contraindications
    OD Tx
    • Beta 1 agonist
    • control arrhythmias, combo treatment for CHF, decrease HR
    • AV block (bradyarrhythmia
    • bradycardia=tx atropine
  10. carbachol-action
    indications
    • muscarinic/nicotinic agonist
    • hypotensive effect, rumen atony, equine colic, constipation/impaction
    • NOT administered IV, resistant to cholinesterase hydrolysis
    • atropine
  11. Glycopyrrolate vs Atropine
    Glycopyrrolate= less CNS penetration and tachycardia, longer half-life, more expensive, doesn't cross BBB, liver metabolism
  12. Glycopyrrolate-actions
    indications
    • muscarinic antagonist
    • antagonize Ach, preanesthetic-decrease secretions, prevent heart block by cardiac depressants, antispasmotic, organophosphate poisoning
  13. glycopyrrolate-contraindications
    side effects
    • fever, colic, glaucoma
    • dry as a bone, red as a beet, and mad as a hatter (similar to sympathetic hypersensitivity)
  14. Phenylephrine-action
    indications
    contraindications
    • mixed alpha agonist
    • increased BP in hypotensive crisis w/o cardiastimulation
    • hypertension, tachycardia
  15. propranolol-action
    indications
    side effects
    contra indications
    • mixed beta antagonist
    • control arrhythmias, increase AV conduction
    • bronchoconstriction (from beta 2)
    • heart failure, asthma, insulin-dependent diabetes ** withdraw gradually-receptor upregulation
  16. yohimbine-action
    main use
    contraindication
    • alpha 2 antagonist
    • xylazine and other alpha 2 agonist reversal
    • seizure prone K9s, renal dz
  17. atropine-action
    indications
    • muscarinic antagonist, crosses BBB
    • antagonize Ach, preanesthetic (decrease secretions, maintain HR)
    • prevent heart block by cardiodepressants, Tx of organophosphate poisoning
  18. atropine contraindications
    side effects
    • fever, colic, glaucoma
    • dry as a bone, red as a beet, and mad as a hatter
  19. dobutamine-action
    indications
    contraindications
    • beta 1 agonist, similar to dopamine
    • maintain BP, control localized bleedine/perfusion, **restore cardiac fxn, shock
    • CHF, short half-life, not effective PO
  20. Isoproterenol-action
    indications
    contraindications
    side effects
    • mixed beta agonist
    • bronchoconstriction tx
    • tachycardia, AV block
    • increases HR, systolic P, decreases diastolic P=decrease BP
  21. phentolamine-action
    indications
    contraindications
    side effects
    • mixed alpha antagonist
    • decrease BP, xylazine reversal
    • hypovolemic shock
    • postural hypotension w/ reflex tachycardia, GI irritability, CNS depression/sedation, impotence
  22. Terbutaline-action
    indications
    contraindications
    • beta 2 agonist
    • asthma Tx, bradycardia Tx
    • hypotension; rapid first pass effect
  23. edrophonium-action
    indications
    • short actine, reversible AChE inhibitor
    • reversal of curare OD, dDx of muscle weakness, miosis, decrease IOP (glaucoma)
  24. physostigmine-action
    indications
    • AChE inhibitor
    • CNS activity, glaucoma, treat myasthenia gravis, ruminal/GI stimulant, reverse muscle relaxants
  25. Neostigmine-action
    indications
    side effects
    • long lasting, reversible AChE Inhibitor
    • glaucoma, treat myasthenia gravis, ruminal/GI stimulant, reverse muscle relaxants, doesn't cross BBB
    • nausea, vomiting, diarrhea, salivation, sweating, miosis, hypotension, bradycardia, bronchospasm
  26. praladoxine-action
    indications
    containdications
    • reactivates phosphorylated forms of AChE
    • KNOWN organophosphate poisoning
    • carbamate poisoning
  27. what happens during organophosphate poisoning and what are some treatments?
    • organophosphates inhibit the action of acetylcholinesterase.
    • Txs: Praladoxime, glycopyrrolate,
  28. Parathion-action
    indications
    contraindications
    • irreversible organophosphate AChE inhibitor
    • organophosphate poisoning
    • SLUD, Toxic

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