Pharmacology Chapter 4

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Pharmacology Chapter 4
2010-01-05 18:59:47

Foundations and Principles of Pharmacology Chapter 4
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  1. Pharmacokinetics
    what the body does to the drug
  2. Pharmacodynamics
    what the drug does to the body
  3. Agonist
    drug attaches to receptor site and activates the receptor; the drug has an action similar to the body's own chemicals, and the chemical response is usu good.
  4. Antagonist
    Drug attaches at drug receptor site, but then remains chemically inactive; no chemical drug response is produced but the drug prevents activation of the receptor.
  5. Partial Agonist
    Drug attaches at receptor site, but only a slight chemical action is produced.
  6. Absorption
    involves the way a drug enters the body and passes into bodily fluids and tissues. takes place through preocesses of diffusion, filtration, and osmosis.
  7. Solubility
    the ability of a medication to dissolve
  8. Enteral
    directly into the gastrointestinal (GI) tract through oral, nasogastric tube, or rectal administration.
  9. Parenteral
    directly into dermal, subcutaneous, or intramuscular tissue, epidurally into the cerebrospinal fluid, or into the bloodstream through intravenous (IV) injections
  10. Percutaneous
    through topical (skin), sublingual (under tongue), buccal (against the cheek), or inhalation (breathing)
  11. Distribution
    the ways that drugs move by means of circulating body fluids to their sites of action in the body.
  12. Diffusion
    movement from a region of higher concentration to one of lower concentration.
  13. Osmosis
    the diffusion of fluid through a semipermeable membrane; the flow is primarily from the less dense solution to the more dense solution.
  14. Filtration
    the passage of a substance through a filter or through a material that prevents passage if certain molecules
  15. Biotransformation
    when medications are broken down into smaller usable parts, primarily in the liver, through a series of complex chemical reactions until they become chemically inactive
  16. first-pass
    when most of the medicine goes very quickly to the liver, a lot medication is inactivated
  17. Excretion
    when all inactive chemicals, chemical by-products, and waste (metabolites) finally break down through metabolism and are removed from the body
  18. Half-life
    the lenght of time it takes for a drug to metabolize and be excreted
  19. Idiosyncratic responses
    strange, unique, or unpredicted responses to a drug
  20. Hypersensitivity
    an increased reaction to a drug
  21. Anaphylactic response
    life-threatening reaction to a drug
  22. Allergic response
    an antigen-antibody reaction to a drug. the body develops hives, rash, itching, or swelling.