On right is hepatic adenoma composed of cells that closely resemble normal hepatocytes
Neoplastic liver tissue disorganized, normal lobular architecture not present
Malignant cells of hepatocellular carcinoma on right
Well differentiated and interdigitate with normal, larger hepatocytes on left (normal)
Metastatic adenomcarcinoma in lymph node
Squamous cell carcinoma with nests of polygonal cells with pink cytoplasm and distinct cell borders
Nuclei hyperchromatic and angular
Renal cell carcinoma
Neoplastic cells have clear cytoplasm and are arranged in nests with intervening blood vessels
"clear cell carcinoma"
Large polygonal cells (or spindle cells) havce pleiomorphic nuclei which contain prominent nucleoli
Neoplasm is making brown melanin pigment
the normal colonic epithelium at the left contrasts with the atypical epithelium of the adenomatous polyp at the
right. Nuclei are darker and more irregularly sized and closer together in the adenomatous polyp than in the normal mucosa. However, the overall difference between them is not great, so this benign neoplasm mimics the normal tissue quite well and this, therefore, well-differentiated.