Coagulation I

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Coagulation I
2010-09-28 16:12:46
Coagulation hematology

Coagulation I
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  1. platelet adhesion to exposed collagen within the endothelial of the vessel wall. However, will be ineffective over time, requires 2nd response.
    Primary Hemostasis
  2. ezymatic activation of coagulation cascade which stabilizes fragile clot formed during primary hemostasis.
  3. What component when initial response is vasoconstriction, reducing blood flow past site of injury.
    Vasculature component
  4. What component when aggregation of platelets at injured site due to collagen exposure
    Platelets component
  5. What component when coagulation factors-coagulation cascade activated due to blood vessel injury.
    Plasma component
  6. What component is when stable clot is dissolved
  7. What charge is endothelial cells?
    negative-to repel platelets
  8. What accelerates conversion of plasminogen to plasmin?
    Tissue plasminogen activator (TPA)
  9. About how long does platelets stay in circulation?
    10 days
  10. What is the normal peripheral count of platelets?
  11. What is the function of the peripheral of platelets?
    adhesion and aggregation
  12. What is the function of sol-gel?
    contraction and support
  13. What is the function of the platelet organelle?
    Storage and secretion of granule contents
  14. What two glycoproteins are missing in BSS?
    GPIb and GPV
  15. What two plt glycoproteins are missing in Glanzmann's?
    GPIIb and GPIIa
  16. What systen in the Sol Gel zone causes surface membrane to increase to exocytose granule contents?
    Open Canaliculi System
  17. What protein allows for contraction of tubules?
  18. What are the steps of platelet plug formation?
    • 1. platelet adhesion
    • 2. platelet aggregation
    • 3. platelet plug
    • 4. Fibrin stabilized
  19. The release of what from dense bodies into sol gel causes contractile wave with release of ADP and serotonin resulting in plt aggregation and adhesion.
    Ca 2+
  20. What does the endothelial cell release to act as a brigde between plt and subendotheium lining?
    vWF- HMW
  21. Where is thrombaxane produced from?
    Arachidonic acid
  22. What step does aspirin inhibit in the thromboxane A2 pathway?
  23. What type of disease is Inherited Hemorrhagic Telangietasia?
    Inherited Vascular Disorder (characterized by many small thin walled capillaries and small veins in mucosa. Plt function test and coagulation tests are normal)