Histology

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Author:
Anonymous
ID:
39096
Filename:
Histology
Updated:
2010-10-02 13:52:39
Tags:
Connective Tissue
Folders:

Description:
D1 Fall Mid2
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  1. Connective Tissue Composition
    • • Cells (fibroblasts, immune, vascular)
    • • Fibers (collagen, elastic, reticular)
    • • Ground substance (glycosaminoglycans, proteoglycans, glycoproteins)
  2. Connective Tissue Building Block
    • • Ground substance
    • • Structual glycoproteins
    • • Basement membrane
    • • Connective Tissue Fibers (Collagen, Elastic, Reticular)
    • • Connective Tissue Cells (Fibroblasts, Adipocytes, Macrophages, Plasma cells, Mast cells)
  3. ESM
    ground substance with variety of fibers and structural glycoproteins that mediate adhesion of cells to the matrix
  4. Ground Substances
    Location:
    Composition:
    Mechanical property:
    • • Extracellular semi-fluid material in connective tissue.
    • • Composed of polysaccharides (glycosaminoglycans [GAGs]).
    • Hyaluronic acid is the dominant polysaccharide.
    • Others polysaccharides are linked to proteins to form proteoglycans.
    • • GAGs are hydrophilic and attract water (extracellular fluid).
    • • Mechanical properties of ground substance and extracellular fluid are reinforced by connective tissue fibers.
    • (Its an empty spot in a microscope view)
  5. Structural Glycoprotein
    Location:
    Examples:
    Function:
    • • Proteins bound to polysaccharides
    • • Examples: fibronectin, laminin, tenascin
    • • Functions include cell adhesion and role in extracellular matrix organization
  6. Basement Membrane
    • • Composed of extracellular matrix proteins. (Collagen type IV, fibronectin, laminin, entactin, and GAGs)
    • • Interfaces connective tissue/parenchymal cells.
    • • Provides support and adhesion of parenchymal cells.
    • • Acts as a barrier and permeability filter
    • • Maintains differentiated functions
  7. Sclerodermia
    Autoimmune where excessive collagen deposited throughout body. Possibly fatal
  8. Elastic skin
    • Genetic defect where collagen is not assembled correctly/ Conversion of
    • procollagen to mature collagen is blocked
  9. Connective Tissue Fiber
    • Collagen
    • Elastic
    • Reticular
  10. Collagen
    • • Type 1: bone, skin, tendon, etc
    • • Type 2: cartilage
    • • Type 3: skin, vessels, reticular fibers
    • • Type 4: basement membranes
    • (1,2,3 form fibers - 4 is mesh)

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