Card Set Information
D1 Fall Mid2
Connective Tissue Composition
• Cells (fibroblasts, immune, vascular)
• Fibers (collagen, elastic, reticular)
• Ground substance (glycosaminoglycans, proteoglycans, glycoproteins)
Connective Tissue Building Block
• Ground substance
• Structual glycoproteins
• Basement membrane
• Connective Tissue Fibers (Collagen, Elastic, Reticular)
• Connective Tissue Cells (Fibroblasts, Adipocytes, Macrophages, Plasma cells, Mast cells)
ground substance with variety of fibers and structural glycoproteins that mediate adhesion of cells to the matrix
• Extracellular semi-fluid material in connective tissue.
• Composed of polysaccharides (glycosaminoglycans [GAGs]).
Hyaluronic acid is the dominant polysaccharide.
Others polysaccharides are linked to proteins to form proteoglycans.
• GAGs are hydrophilic and attract water (extracellular fluid).
• Mechanical properties of ground substance and extracellular fluid are reinforced by connective tissue fibers.
(Its an empty spot in a microscope view)
• Proteins bound to polysaccharides
: fibronectin, laminin, tenascin
• Functions include cell adhesion and role in extracellular matrix organization
• Composed of extracellular matrix proteins. (Collagen type IV, fibronectin, laminin, entactin, and GAGs)
• Interfaces connective tissue/parenchymal cells.
• Provides support and adhesion of parenchymal cells.
• Acts as a barrier and permeability filter
• Maintains differentiated functions
Autoimmune where excessive collagen deposited throughout body. Possibly fatal
Genetic defect where collagen is not assembled correctly/ Conversion of
procollagen to mature collagen is blocked
Connective Tissue Fiber
• Type 1
: bone, skin, tendon, etc
• Type 2
• Type 3
: skin, vessels, reticular fibers
• Type 4
: basement membranes
(1,2,3 form fibers - 4 is mesh)