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Connective Tissue Composition
- • Cells (fibroblasts, immune, vascular)
- • Fibers (collagen, elastic, reticular)
- • Ground substance (glycosaminoglycans, proteoglycans, glycoproteins)
Connective Tissue Building Block
- • Ground substance
- • Structual glycoproteins
- • Basement membrane
- • Connective Tissue Fibers (Collagen, Elastic, Reticular)
- • Connective Tissue Cells (Fibroblasts, Adipocytes, Macrophages, Plasma cells, Mast cells)
ground substance with variety of fibers and structural glycoproteins that mediate adhesion of cells to the matrix
- • Extracellular semi-fluid material in connective tissue.
- • Composed of polysaccharides (glycosaminoglycans [GAGs]).
- Hyaluronic acid is the dominant polysaccharide.
- Others polysaccharides are linked to proteins to form proteoglycans.
- • GAGs are hydrophilic and attract water (extracellular fluid).
- • Mechanical properties of ground substance and extracellular fluid are reinforced by connective tissue fibers.
- (Its an empty spot in a microscope view)
- • Proteins bound to polysaccharides
- • Examples: fibronectin, laminin, tenascin
- • Functions include cell adhesion and role in extracellular matrix organization
- • Composed of extracellular matrix proteins. (Collagen type IV, fibronectin, laminin, entactin, and GAGs)
- • Interfaces connective tissue/parenchymal cells.
- • Provides support and adhesion of parenchymal cells.
- • Acts as a barrier and permeability filter
- • Maintains differentiated functions
Autoimmune where excessive collagen deposited throughout body. Possibly fatal
- Genetic defect where collagen is not assembled correctly/ Conversion of
- procollagen to mature collagen is blocked
- • Type 1: bone, skin, tendon, etc
- • Type 2: cartilage
- • Type 3: skin, vessels, reticular fibers
- • Type 4: basement membranes
- (1,2,3 form fibers - 4 is mesh)