CHAPTER 34- SPLEEN

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Anonymous
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39459
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CHAPTER 34- SPLEEN
Updated:
2010-10-03 21:13:13
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spleen
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CHAPTER 34- SPLEEN
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  1. Name two end arteries related to the spleen:
    • 1) splenic artery
    • 2) short gastrics
  2. Whats the relationship between splenic vein and artery?
    the splenic vein is posterior and inferior to the splenic artery
  3. Name a function of the spleen (immunologic):
    spleen serves as an antigen-processing center for macrophages; largest producer of IgM
  4. Red pulp:
    • 1) 85% of spleen
    • 2) acts as a filter for aged or damaged RBCs
    • 3) Pitting- is the removal of abnormalities in RBC membrane
    • -Howell- Jolly bodies- nuclear remnants
    • -Heinz bodies- hemoglobin
    • 4) Culling- removal of less deformable RBCs
  5. White pulp:
    • 1) spleen is 15% white pulp
    • 2) immunologic function; contains lymphocytes and macrophages
    • 3) major site of bacterial clearance that lacks preexisting antibodies
    • 4) site of removal of poorly opsonized bacteria, particles, and cellular debris
    • 5) antigen processing occurs with interaction between macrophages and helper T cells
  6. Tuftsin-
    an opsonin, facilitates phagocytosis --> produced in spleen
  7. Properidin:
    activates alternative complement pathway- produced in the spleen
  8. Hematopoesis
    occurs in spleen before birth and in conditions like myeloid dysplasia
  9. Accessory spleen
    most commonly found at splenic hilum (20%)
  10. Indication for splenectomy:
    • ITP far greater than TTP
    • - ITP most common nontraumatic condition requiring splenectomy

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