Card Set Information
Name 8 common symptoms of hypothyroidism.
Mental slowing and physical sluggishness
Normal or decreased appetite with wt. increase
Coarse & dry skin
Intolerance of cold /hypothermia
Name 5 causes of primary hypothyroidism.
: esp. Hashimoto thyroiditis
: 10% of postpartum women, transient (2-4 mo)
Subacute granulomatous thyroiditis
: e.g. amiodarone, interferon alpha, thalidomide, lithium, and stavudine.
: radiotherapy, thyroidectomy
: worldwide, iodine deficiency is the most common cause of hypothyroidism
Name 5 causes for central hypothyroidism.
Tumors impinging on the hypothalamus
History of brain irradiation
Drugs (e.g., dopamine, lithium)
Outline 4 Ix for hypothyroidism.
Autoimmune antibodies - anti-TPO, antimicrosomal antibodies)
Ultrasound to detect nodules or infiltration
FNAC to exclude malignancy
TFT - TSH high, T4 low
Name 3 histopathological features in Hashimoto's disease glands.
Diffuse lymphocyte and plasma cell infiltration
Epithelial cells with abundant eosinophilic, granular cytoplasm = Hurthle cells
Interstitial CT is increased
Destruction of the function thyroid tissue
What are 2 other autoimmune diseases associated with Hashimoto's?
Diabetes Type I
B cell lymphomas
What is the cause for peripheral neuropathy in hypothyroidism?
Carpal tunnel syndrome with myxedema:
mucopolysaccharide-rich edema accumulates in the skin, subcutaneous tissue, and visceral sites.