Periodontal Immunology

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Author:
thezidane
ID:
42199
Filename:
Periodontal Immunology
Updated:
2010-10-14 15:14:40
Tags:
periodontology
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Description:
periodontal immunology
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  1. list 3 soluble bacterial enzymes
    • 1. AA: leukotoxin
    • 2. Gm-: LPS endotoxin
    • 3. Gm+: Lipoteichoic acid
  2. list 2 immunodominant molecules
    • 1. Arg1-protease
    • 2. Fimbrillin type I and III
  3. list 3 metabolic waste products from bacteria
    • 1. ammonia
    • 2. hydrogen sulfide
    • 3. indole
  4. list 2 fatty acids that are toxic to host tissues
    • 1. butyric acid
    • 2. proprionic acid
  5. list 1 chemoattractant peptide
    fMLP
  6. define Defensin and give 2 examples of them
    • Defensin: protein that creates pores in cells to allow efflux of essential ions causing cell death
    • 1. Alpha: secreted by neutrophils
    • 2. Beta: secreted by epithelial cells
  7. List 2 cytokines released by the oral epithelium
    • 1. IL-1b to induce inflammation
    • 2. IL-8 chemokine
  8. Which TLRs are responsible for Gm- bacteria?
    4 and 5
  9. Which TLRs are responsible for flagellated Gm+ bacteria?
    2 and 5
  10. what is one problem with TLRs
    they do not distinguish between pathogenic and commensal bacteria
  11. list 3 cytokines released by Th1 cells
    • 1. IL-2
    • 2. IFN-g
    • 3. TNF-a
  12. list 5 cytokines released by Th2 cells
    IL-4, 5, 6, 10, 13
  13. Th1 cells contribute to which type of immune response?
    cell mediated immune response
  14. Th2 cells contribute to which immune response?
    humoral immune response
  15. MHC I recognize what type of antigen?
    cytosolic proteins and killing of infected cells
  16. MHC II recognize what type of antigen
    extracellular and intravesicular pathogens
  17. how do Cytotoxic T cells relate to periodontitis
    not many Tc cells are found in periodontitis suggesting that viruses and invasive bacteria are not major players
  18. What cytokine is the tipping point between stable and progressive periodontitis?
    IL-10
  19. How are B-cells triggered to respond?
    they are triggered in response to soluble antigens
  20. Define 2 types of B-cells
    • 1. Conventional: produce antibodies against bacteria
    • 2. Autoreactive: produce auto-antibodies, levels do not decrease after treatment
  21. Explain the discrepancy between antibody avidity
    IgG2 < IgG1, IgG2 found in large numbers of LAP as IgG2 recognizes carbohydrate antigens (LPS of Gm- bacteria!)
  22. What is the balance of Th1/2 cells in chronic periodontal lesions?
    Th2 cells outnumber Th1 cells in chronic periodontal lesions
  23. What are the most active secretory cells in advanced periodontal lesions?
    plasma cells

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