ACP Ipratropium bromide

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  1. Ipratropium bromide
    Trade name:
    Atrovent
  2. Ipratropium bromide
    Class:
    • anti-cholinergic
    • bronchodilator
  3. Ipratropium bromide
    Action:
    • It blocks the muscarinic cholinergic receptors in the smooth muscles of the bronchi in the lungs
    • - inhibiting bronchoconstriction and mucus secretion.
    • - a non-selective muscarinic antagonist, and does not diffuse into the blood, which prevents systemic side-effects.
    • - results from decreased concentrations of cyclic guanosine monophosphate (cyclic GMP).
    • - Decreased levels of cyclic GMP produce local, not systemic, bronchodilation
  4. Ipratropium bromide
    Indications:
    • bronchospasm in asthma
    • chronic bronchitis
    • emphysema
  5. Ipratropium bromide
    Contraindications:
    Hypersensitivity to drug or atropine or its derivatives
  6. Ipratropium bromide
    Adverse effects:
    • Palpitations
    • Dizziness
    • Anxiety
    • Headache
    • Nervousness
  7. Ipratropium bromide
    Onset:
    1-3 min
  8. Ipratropium bromide
    Duration:
    • Duration: 4-6 hrs,
    • Peak 1-2hrs
    • Half life 2hrs
  9. Ipratropium bromide
    Adult Dosage
    • 250 –500 mcg via nebulizer with Salbutamol (mixed)
    • - repeat up to two times if necessary
    • - Normally only 1-2 doses in other conditions (eg. emphysema, chronic bronchitis)
    • Combivent: 2.5 – 5.0 ml nebule – repeat q 10 minutes prn (not to exceed max dose for Atrovent )
    • MDI: minimum 1- 4 puffs prn; max 10
    • - (give after salbutamol; ipratropium has a much slower onset of action)
  10. Ipatropium bromide
    Pediatric Dosage:
    • (ages 5-11)
    • – 25-250 mcg via nebulizer with salbutamol (mixed) repeat up to times two if necessary
    • MDI: minimum 2 puff prn; max 4 (give after salbutamol; ipratropium has a much slower onset of action)
    • safety and efficacy in children under 12 years of age haven’t been established.
  11. Ipratropium bromide
    Route:
    Nebulizer or metered dose inhaler
  12. Ipratropium bromide
    Interactions/Precautions:
    • Hypersensitivity to soy lecithin or related food products (soybeans, peanuts)
    • Patients with narrow angle glaucoma
    • Be careful to avoid accidental release into the eyes (use mouth piece neb if possible)
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42501
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ACP Ipratropium bromide
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Flash card for all the details about Ipratropium bromide
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