type of drug that relaxes skeletal muscle:
- acts as a depolarizing agonist at ACh receptor
- phase I, it binds to receptor and causes depolarization, not metabolized effectively at synapse, so membranes remain depolarized and unresponsive to subsequent impulses (depolarizing block)
- in phase II, acts as if channel is in prolonged closed state (desensitized)
- can be reversed by acetylcholinesterase inhibitors but only during phase II!!!
- DEPOLARIZING neuromuscular blocking drugs