ABSITE ch 34 spleen.txt

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ABSITE ch 34 spleen.txt
2010-01-17 11:59:34
spleen ABSITE

ABSITE ch 34 spleen
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  1. Location of splenic vein (with respect to splenic artery)
    Posterior, inferior
  2. Organ that is the largest producer of IgM
  3. Filter for aged or damaged RBCs
    Red pulp
  4. Removal of abnormalities in RBC membranes (job of the spleen)
  5. Nuclear remnants in RBCs
    Howell Jolly bodies
  6. Hemoglobin deposits in RBCs
    Heinz bodies
  7. Portion of spleen containing lymphocytes and macrophages
    White pulp
  8. Site of spleen that does bacterial clearance (that lack pre-existing antibodies)
    White pulp
  9. Blood supply to spleen
    Splenic artery, short gastrics, left gastroepiploic
  10. An opsonin that facilitates phagocytosis
  11. An enzyme that activates alternative complement pathway
  12. Most common location for accessory spleen
    At splenic hilum
  13. Most common nontraumatic condition requiring splenectomy
  14. Disease with antiplatelet antibodies, petechiae, gingival bleeding, bruising
  15. Medical treatments for ITP
    Steroids, plasmapheresis, gammaglobulin (if steroid resistant)
  16. Disease with loss of platelet inhibition leading to thrombosis and infarction plus thrombocytopenia, fevers, mental status changes, renal dysfunction
  17. Treatment of TTP
    Plasmapheresis, steroids, ASA
  18. Bacteria causing postsplenectomy sepsis syndrome (3)
    S. pneumoniae, H. influenzae, N. meningitides
  19. Vaccines needed before splenectomy
    Pneumococcus, meningococcus, H. influenzae
  20. Changes in CBC post splenectomy
    Inc RBCs, inc WBCs, inc platelets
  21. Most common splenic tumor
  22. Most common malignant splenic tumor
    nonHodgkin's lymphoma
  23. indication for removal of splenic cysts
    symptomatic, >10cm
  24. causes of secondary hypersplenism
    inc venous pressure (portal HTN, CHF), cancer (leukemia), chronic inflammatory disease (Felty's syndrome, SLE, sarcoid), myeloproliferative disease, amyloidosis, AIDS, hemolytic anemias, polycythemia vera
  25. indications for splenectomy associated with hypersplenism
    ANY primary hypersplenism (rare), CLL, CML, NHL, Hodgkin's, hairy cell, hemolytic anemia, sarcoid
  26. Rheumatoid arthritis, hepatomegaly, splenomegaly
    Felty's syndrome
  27. Lipid metabolism disorder leading to splenomegaly
    Gaucher's disease
  28. Most common congenital hemolytic anemia requiring splenectomy
  29. Spectrin defect causing deformed RBCs and splenic sequestration
  30. Treatment of spherocytosis
  31. Spectrin and protein 4.1 deficit causing deformed RBCs and splenic sequestration
  32. Congenital hemolytic anemia causing altered glucose metabolism
    Pyruvate kinase deficiency
  33. Congenital hemolytic anemia precipitated by infection, certain drugs, and fava beans
    G6P deficiency
  34. Replacement of HgbA with HgbS, causes splenic auto-infarction
    Sickle cell anemia
  35. Persistent fetal HgbF causing anemia, pallor, growth retardation, head enlargement
  36. Hodgkin's disease class A
  37. Hodgkin's disease class B
    Symptomatic (night sweats, fever, weight loss)
  38. Hodgkin's disease with 2 noncontiguous areas on the same side of diaphragm
    Stage II
  39. Hodgkin's disease with involvement on both sides of the diaphragm
    Stage III
  40. Most common subtype of Hodgkin's disease
    Nodular sclerosing
  41. Cells seen on cytology for Hodgkin's
    Reed Sternberg cells
  42. Most common subtype of NonHodgkin's lymphoma
    B cell lymphoma (90%)
  43. Treatment of NHL
    XRT, chemotherapy (vincrisine, cyclophosphamide, prednisone, Adriamycin)
  44. Treatment of Hodgkin's lymphoma
    XRT, chemotherapy (vincristine, cyclophosphamide, prednisone, procarbazine)
  45. Causes of spontaneous splenic rupture (6)
    Mononucleosis, malaria, sepsis, sarcoid, leukemia, polycythemia vera
  46. Splenic implants, often caused by trauma
  47. Most common cause of splenic artery or splenic vein thrombosis