Home > Flashcards > Print Preview

The flashcards below were created by user Anonymous on FreezingBlue Flashcards. What would you like to do?

  1. Mechanism of Action
    Interfere with bacterial synthesis of folic acid which leads to a decrease in tetrahydrofolic acid which is necessary for purine, thymidine and DNA synthesis.
  2. Absorption
    Good oral bioavailablity
  3. Sulfisoxazole
    • Short Acting
    • QID
    • Used to treat Otitis Media and sometimes UTIs (good urine solubility)
  4. Sulfadiazine
    • Short Acting
    • Passes into CSF due to minimal protein binding
    • Used in combination to treat nocardial infections and toxoplasmosis.
    • Low urine solubility
  5. Sulfamethoxazole
    • Intermediate Acting
    • Less solube in urine & slower excretion then sulfisoxazole
    • BID
    • Combined with trimethoprim for synergistic bactericidal effect.
  6. Sulfacetamide
    • Ophthalmic preparation used to treat superficial infections of the eye.
    • Doesn't penetrate systemically well due to PK.
  7. Mafenide
    • Broad Spectrum topical sulfa
    • Used primarily in burn patents
    • Effective against Pseudomonas
    • Diffuses well through devascularized areas.
    • Mafenide and it's metabolite are carbonic anhydrase inhibitiors. (Used with caution in patient with renal or pulmonary insufficiencies)
    • Adverse effects: Hypersensitivity, fungal colonization, local pain, and burning sensation.
  8. Silver Sulfadiazine
    • Tropical Sulfa used in burn patients
    • Effective against pseudomonas
    • Less pain than with mafenide and few applications needed
    • Sulfadiazine is absorbed & high concentrations can be achieved.
    • Crystaluria can be a problem.
  9. Sulfasalazine
    • Combination of a sulfa and antiinflammatory agent.
    • Used in treatment of IBD
    • Poor absorbed from GI tract
    • Metabolized by bacteria to sulfapyridine and 5-aminosalicylic acid.
  10. Trimethoprim-Sulfamethoxazole (Bactrim)
    Mechanism of Action
    • TMP-SMX
    • Combines two agents that inhibits bacteria synthesis at two sequential steps.
    • Bactericidal-synergistic activity
    • Slow development of resistance
  11. Trimethoprim-Sulfamethoxazole (Bactrim)-Mechanisms of Resistance
    • Increased production of PABA
    • Synthesis of altered enzymes
    • Increased production of dihydropteroate synthetase
    • Reduced Drug uptake
  12. Trimethoprim-Sulfamethoxazole (Bactrim) - Dosing
    • Optimal synergistic ratio of serum conc. is 1:20.
    • Achieved by a fixed dose ratio of 1:5.
  13. Trimethoprim-Sulfamethoxazole (Bactrim) - Spectrum of Activity
    • Gram Positive - MSSA, MRSA, S. epidermidis, S. pneumoniae.
    • Gram Negative - Most enterobacteriaceae, H. flu, M. catarrhalis, Salmonella, Shigella
    • Not active againist Pseudomonas and poor anaerobic coverage.

Card Set Information

2010-10-20 16:57:47

Sulfonamide Drugs
Show Answers:

What would you like to do?

Home > Flashcards > Print Preview