AA catabolism and Urea cycle.txt
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Why do we need to remove Nitrogen from AA?
Nitrogen containing compounds can't be digested in the liver
Where does the urea cycle occur?
What is the role of glutamate dehydro?
- Remove NH3 from glutamate using NAD+Make Glutamate from alpha-ketoglut. using NADPH + NH3
How many ATP required for one Urea molecule?
Where is CPS-1 found?
What mops up the extra ammonia after the Urea cycle is finished?
- Glutamine synthetase (to form glutamine)
- Low Vmax, Low Km
Why is Ammonia so dangerous?
- It can cross the BBB and can increase glutamine in the brain
- Leads to encephalopathy
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