Path II Quiz 2
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Path II Quiz 2
Path II Lecture
NephrItic Syndrome vs NephrOtic Syndrome:
-Azotemia & oliguria.
-Immune, inflammation, can't pee or see.
-Piss it all away & get fat (edema & hyperlipidemia).
What is the name of hereditary glomerulonephritis which develops in early childhood?
Results in renal failure in the 20's.
Is Alport Syndrome associated with Nephrotic Syndrome or Nephritic Syndrome?
What are the 4 characteristics associated with Alport Syndrome?
True or false: Chronic Glomerulonephritis is the end stages of Glomerulonephritis, & is associated only with Nephritic Syndrome.
False: both nephritic & nephrotic syndrome.
What are the 5 clinical manifestations of nephrOtic syndrome?
: loss >3.5 mg/dL per day, due to damage to glomerulus.
: results in oncotic pressure changes.
Generalized swelling (or edema)
: due to increased aldosterone resulting in decreased blood flow.
What are the 6 major manifestations of nephrOtic syndrome?
1. Increased permeability of glomerulus for proteins (predominately albumin).
2. Loss of proteins.
3. Abnormal albumin & globulin concentration.
4. Inversion of albumin-globulin ratio.
5. Fatty casts in urine.
6. Edema (non-pitting).
What is meant by the inversion of the albumin-globulin ratio associated with nephrOtic syndrome?
Ratio becomes less than 1.
What are the 3 main causes of nephrOtic syndrome?
Primary glomerular diseases
: lipid nephrosis, membranous glomerulonephritis, focal glomerulonephritis, membranoproliferative glomerulonephritis.
: diabetes mellitus or amyloidosis.
: end stage of glomerulonephritis.
Lipid nephrosis is characterized by heavy proteinuria, protein in the walls of the convoluted tubules, & is found in young children. Is it associated with nephritic or nephrotic syndrome?
walls loaded with protein.
develops in canals (convoluted tubules).
True or false: Focal glomerulosclerosis occurs in the elderly, and is a mild disease.
Develops into chronic glomerulonephritis.
Switches from acute to chronic.
Occurs in young people.
Amyloidosis leads to the accumulation of what substance?
Extracellular deposition of protein.
Within 1-3 results in chronic renal failure.
Most vulnerable organs
: kidney, heart, liver.
Chronic glomerulonephritis leads to the development of chronic renal failure within how long of a period?
20-25 years = slow progression.
End stage of glomerulonephritis.
Kidney becomes coarse & granular due to scar tissue.
Kidney size is smaller (contracted).
Waste products are released via alternative ways.
Which 3 systems are involved with alternatively ridding the body of waste products during chronic glomerulonephritis?
1. Through the
: vomitting & nausea.
2. Through the
: urine smell on breath.
3. Through the
: looks like frost on the skin, due to nitrogenous crystals.
Frequency of conversions to chronic glomerulonephritis:
Rapidly progressive glomerulonephritis
: most common overall.
: most common nephrOtic.
Post streptococcal glomerulonephritis
: least common.