AA and Catecholamine.txt

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Author:
kepling
ID:
44033
Filename:
AA and Catecholamine.txt
Updated:
2010-10-21 15:22:13
Tags:
AA Catecholamine
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Description:
AA and Catecholamine
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  1. When is Arginine an essential AA?
    Only during rapid fetal growth
  2. What hormone stimulates PNMT?
    Cortisol
  3. What is Alpha-methyldopa use for pharmaceutically?
    hypertension
  4. How are catecholamines recycled?
    Monoamine reuptake (NET, DAT)
  5. What drug inhibits monoamine reuptake?
    Cocaine
  6. What is the role of VMAT-2?
    • Uptake of catecholamines into presynaptic vesicles
    • (H+/Catecholamine antiport)
  7. What is the role of MAO?
    degrade catecholamines into an acid if they are not taken up by their Monoamin reuptake (like NET)
  8. What causes Parkinson's disease?
    • Lack of Dopaminergic neurons
    • Dopamine cannot cross BBB alone
  9. What is the function of Ldopa and what must accompany it to work?
    • It can cross the BBB
    • Helps raise levels of Dopamine by activating AADC
    • Carbidopa is used to inhibit AADC so Dopamine is not created and rejected

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