Pharmacology Exam 3

Card Set Information

Author:
Rx2013
ID:
44049
Filename:
Pharmacology Exam 3
Updated:
2010-10-21 17:26:04
Tags:
Cholinergic Blockers Cholinesterase regenterators
Folders:

Description:
Cholinergic Blockers and Cholinesterase regenterators
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user Rx2013 on FreezingBlue Flashcards. What would you like to do?


  1. CNS Effects of Muscarinic Antagonists
    • drowsiness
    • amnesia
  2. Bronchial effects of muscarinic antagonsists
    • bronchodilation
    • decreased secretion
  3. GI effects of muscarinit antagonists
    • reduced motility & tone
    • constipation
  4. Glands effect of muscarinit antagonists
    dry skin, conjunctiva and mouth
  5. Eye effects of muscarinic antagonists
    • long lasting mydriasis
    • cycloplegia
    • sandy eyes
    • contraindicated in glaucoma
  6. Bladder effects of muscarinic antagonists
    • urinary retention
    • enuresis
  7. Clinical uses of muscarinic antagonists
    • motion sickness
    • dysuria/urgency
    • parkinsonism
    • diarrhea
    • COPD if unresponsive to B2 agonists
    • prevent vagal reflexes during surgery
  8. Most common use for muscarinic antagonists
    • pupil dilation in eye exams
    • contraindicated in narrow angle glaucoma
  9. Muscarinic antagonists are an antidote to
    anticholinesterases and muscarinic agonists
  10. Pralidoxime
    removes inhibitors that inactivate AChE
  11. Toxicities of muscarinic antagonists
    opposite of SLUDGE
  12. CNS Effects of muscarinic antagonist toxicities
    • sedation
    • amnesia
    • delirium
    • coma or convulsions
  13. Contraindications of Muscarinic Antagonists
    • angle-closure glaucoma
    • prostatic hyperplasia
    • acid-peptic disease (non-selective agents)
    • M1 = stomach acid secretion
    • M2 = GI movement
  14. Atropine
    • muscarinic receptor competitive antagonist
    • belladonna alkaloid
  15. Uses for atropine
    • cosmetic (increase pupil size)
    • medicine (decrease diarrhea)
    • poison
  16. Cardiovascular Effects of atropine
    • increased HR
    • increased Strength
  17. Respiratory effects of atropine
    relaxation of bronchial muscles
  18. GI effects with atropine
    decreased motility and secretions
  19. GU effects of atropine
    acts on kidney and ureters
  20. Atropine effects in the EYE
    • blocks sphincter muscle resulting in mydriasis
    • weakens ciliary muscle leading to cycloplegia (loss of accomidation)
  21. Toxic effects of atropine
    • red
    • hot
    • dry
    • mad
    • blind
  22. Scopolamine
    • belladonna alkaloid
    • muscarinic antagonist
    • greater CNS activity
    • more sedative
  23. Use of scopolamine
    • prevent and treat motion sickness
    • preanesthetic (dry secretions)
  24. Synthetic muscarinic antagonists
    • propantheline
    • methantheline
    • tolterodine
  25. propantheline
    • synthetic muscarinic antagonist
    • used for peptic ulcers
    • slows gastric emptying
    • decreases GI tone, motility and secretions
  26. Methantheline
    • synthetic muscarinic antagonist
    • anti-saliva drug
  27. tolterodine
    • synthetic muscarinic antagonist
    • some M3 selectivity
    • treatment of urinary incontinece in adults
  28. Cyclopentolate
    • Antagonist
    • mydriasis
    • cycloplegia
  29. Glycopyrolate
    • antagonist
    • preoperative med
    • IBS
  30. Tropicamide
    • dilation
    • mydriasis
    • cycloplegia
  31. Phenylephrine
    • alpha agonist
    • mydriasis without cycloplegia
    • reverse with pilocarpine or alpha blocker
  32. Ipratropium
    • dry mouth
    • cough
    • metalic taste
    • used for COPD, Asthma and Nasal rhinorrhea
  33. Treatment of reversible AChE inhibition
    Atropine
  34. treatment of irreversible AChE inhibition
    • atropine
    • pralidoxime
  35. Nicotine
    stimulation and blockade of nicotinic receptors in high doses
  36. Competitive nicotinic ganglionic antagonists
    • trimethaphan
    • TEA
    • mecamylamine (low doses)
  37. Non-competitive nicotinic ganglionic antagonists
    • hexamethonium
    • mecamylamine (high doses)
  38. Neuromuscular junction nicotinic competitive antagonist
    • tubocurarine
    • blocks acces to receptor binding site
    • does not cross BBB
  39. Neuromuscular junction depolarizing agents
    • succinylcholine
    • vecuronium
    • pancuronium
  40. CNS effects of ganglionic blockers (nicotinic antagonists)
    • sedation
    • tremor
  41. Eye effects of ganglionic blockers
    • predictable cycloplegia
    • unpredictable pupil effect
    • predominant parasympathetic effect - dilation ?
  42. Cardiovascular effects of nicotinic antagonist ganglionic blockers
    • hypotension
    • moderate tachycardia
  43. Other effects of ganglionic blockers
    • GI constipation
    • urinary retention
    • erection and ejaculation dysfunction
    • increased response to autonomic drugs
  44. Curare
    poison which paralyzes respiratory muscles
  45. Drugs altering the synthesis, release or degradation of ACh
    • hemicholinium
    • botulinium toxin
    • black widow spider venom
    • tetrodotoxin
    • dantroline
  46. Hemicholinium
    ACh reuptake inhibitor
  47. Botulinum toxin
    prevents release of ACh by interfering with Ca2+ influx
  48. Black widow spider venom (latrotoxin)
    increases ACh release
  49. Tetrodotoxin
    Na+ Channel blocker
  50. Dantrolene
    depresses excitation contraction coupling inside muscle cells

What would you like to do?

Home > Flashcards > Print Preview