Pharm

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felizdiaz
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44211
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Pharm
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2010-10-26 21:40:48
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PHARM test 1
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  1. ALPHA RECEPTOR ANTAGONIST
    THESE AGENTS BIND TO ALPHA AND INTERFERE WITH CATECHOLAMINE OR OTHER SYMPATHOMIMETIC

    • PRIMARY RESPONSE IS VASODILATION AND RELAXATION OF SMOOTH MUSCLE
    • STOP EPI BLOCKING INSULIN RELEASE

    • NONSELECTIVE
    • PHENTOLAMINE (REGITINE)
    • PHENOXYBENZAMINE

    • SELECTIVE A 2
    • YOHIMBINE

    • SELECTIVE A2
    • PRAZOSIN
    • TERAZOSIN
    • DOXAZOSIN
    • TAMSULOSIN
  2. PHENTOLAMINE
    • NONSELECTIVE COMP ALPHA
    • REGITINE
    • USE: LOW BP BLOCKS A2 SO UP NE TO UP HR AND CO
    • TX; UP BP DT PHENCHROMCYTOMA (30-70 MCGS/KG)
    • INFILTRATION OF DOPAMINE (2.5-5 MG)
  3. PHEMOXYBENAMINE
    • BLOCK A1 AND A2 1>2
    • CARDIO; OTHRO BP WITH PT OF LOW VOL OR HTN. UP CO
    • OTHER EFFECT: UP INSULIN, SEDATION, NASAL STIFFNESS
    • C USE: PVD( RAYMAUDS), HEMO SHOCK, BP WITH PT OF PHEOCHROMOCYTOMA
  4. YOHIMBINE
    • BLOCK PRESYNAPTIC A2
    • INCREASE NE RELEASE
    • TX; IDOPATHIC OTHRO BP, IMPOTENCE
    • SE; CROSS BBB(TREMORS) HTN, RHIMORRHEA, PARESTHESIAS, DISSOCIATIVE STATES
  5. PRAZOSIN
    • BLOCK PORTSYN A1
    • TX HTN, CHF (DIUTETICS AND CARDIO GLYCOSIDES), BPH
    • CARDIO; LOW SVR CAUSING REFLEX HI HR, LOW VENOUS RETURN AND CO, VASODIL OF VIENS AND ART
    • SE; VERTIGO, FLUID RETENTION, O BP, DRY MOUTH, CONGESTION, UP URINE FREQ, SEX DYSFUNCTION.
    • BLOCK NEOSYPHRINE
  6. TERAZOCIN AND
    DOXAZOCIN
    • BLOCK A1
    • TX MILD TO MED HTN, BPH
  7. TAMULOSIN
    • FLOMAX
    • BLOCK A1C
    • TX; BPH ONLY
  8. BETA BLOCKERS
    • BLOCK BETA RECEPTORS
    • EFFECT HEART AND SMOOTH MUSCLE OF THE LUNGS
    • SHOULD BE CONTINUED THROUGH PERIOP PERIOD.
    • PROPRANOLOL IS THE STANDARD TO WHICH OTHERS ARE COMPARED
    • WATCH FOR LOW HR, UNCOM HF, MASKING OF LOW SUGAR
    • CAUSE UPREGULATION WITH CHRONIC USE
    • CAN BE REVERSED

    • NONSELECTIVE
    • PROPRANOLOL
    • NADALOL
    • TIMOLOL
    • PINDOLOL

    • SELECTIVE
    • METOPROLOL
    • ATENOLOL
    • ACEBUTOLOL
    • BETAXOLOL
    • ESMOLOL
  9. INTRINSIC SYMPATHOMIMECTIC ACTIVITY
    • PARTIAL BETA ANATGONIST
    • LESS DIRECT BETTER FOR PT WITH POOR LVF
  10. PROPRANOLOL
    • B1 AND B2 ANGONIST
    • CARDIO; LOW HR, CONTRACTILITY AND CO, UP PVR AND CORNARY VAS RES, LOW HEART O2 DEMAND
    • PK; PROTIEN BOUND(90-95%) HIGH 1ST PASS, IV 0.5 MG VS 40-800 MG PO), META LIVER BUT DECREASE BLOOD FLOW AND ITS OWN META

    CAUSE OPIOIDS TO HAVE 2-4X EFFECT
  11. NADALOL
    • BLOCK B1 AND B2
    • HALF LIFE 20-40 HOURS
    • NOT META EXCRETED IN URINE AND BILE
  12. TIMOLOL
    • BLOCK B1 B2
    • TX GLAUCOMA
    • IF LOW BP AND HR OCCUR THEN ATROPINE WITH NOT WORK
    • SE; APENA
  13. SOTALOL
    • NONSELECTIVE BETA
    • CLASS III ANTIARRHYMIC
    • UP QT INTERVAL, REFACTORY, ACTION POTENTIAL,
    • TX; VT
  14. METOPROLOL
    • BLOCK B1
    • CARDIO LOW HR CO CONTRACTILITY
    • OK FOR PT WITH COPD
    • INCREASE DOSE LOW SELECTIVITY OF B1
  15. ATENOLOL
    • MOST SELECTIVE B 1 BLOCKER
    • PREOP ADMINISTRATION IN PT WITH CAD LOW POST OP MI BUT UP STROKE AND DEATH

    • SE FATIGUE LOW HR BP
    • EXCRETED VIA KIDNEYS LOOK AT FUNCTION
  16. BETAXOLOL
    • BLOCK B1 BUT SOME B2
    • TX; HTN, GLAUCOMA
    • META; LIVER
  17. ESMOLOL
    • B1 BLOCKER (IV ONLY)
    • DOSE;1ST 0.5 MG'KG OVER 1 MIN, FULL EFFECT 5 MINS LAST 10-30 MIN
    • TX ADVERSE SYSTEMIC BP AND HR DURING ETT
    • HALF TIME 9 MINS
    • PROTIEN BOUND 55% LOW EXCRTION IN URINE
    • SE; LOW BP, DIAPHORESIS, N/V, HA, CONFUSION, DIZZY,
    • DECREASE PROPOFOL EFFECT
  18. LUNG UPTAKE OF MEDS
    • THIS MEDS QUICKLY DISTRIBUTE TO LUNGS WHERE THEY ARE INACTIVE
    • FENTANLY, ALFENTANIL, MEPERIDINE
  19. ENZYME INHIBITION
    • LOW META RATE OF MEDS
    • ACUTE ETOH
    • CIMETIDINE VALPRO ACID
    • NEFAZODNE ERYTHROMYCIN
    • AMIODARONE
    • DILTIAZEM
    • VERAPAMIL
    • PROTEASE INHIBITORS
  20. ENZYME INDUCTION
    • MED THAT UP META OF OTHER MEDS
    • CHRONIC ETOH, SMOKING, RIFAMPIN, PHENYTION, PHENOBARBITOL, CARBAMAZEPINE
  21. ESTER- HYROLYSIS
    • BREAK DOWN MED AT SITE WITH HYDROLYSIS
    • SUCCS, MIVACURIUM
  22. PROTIEN BINDING
    • MEDS THAT BIND TO PROTIEN
    • WARFARIN, ASA, PHENYTOIN, PROPRANOLOL, DIAZEPAM
  23. HOFFMAN ELIMINATION
    MED BREAK DOWN ON OWN WITH pH AND TEMP

    ATRACURUIM, CISATRACURUIM
  24. COCKCROFT- CAULT
    CR CLEARANCE
    • (140-AGE)XTBW/ 72 X CREATININE
    • O .85 FOR GIRLS
    • IBW
    • M 50+(2.3 X OVER 5FT)
    • F 45.5+(2.3 X OVER 5FT)
  25. ZERO ORDER KINETICS
    • DRUG ELIMATION AT A CONSENT RATE OF TIME NOT BY AMOUNT.
    • ASA, ETOH, PHENYTOIN
  26. SELECTIVE BETA 2 AGONIST
    • BINDS TO B2 SOME B1
    • C USE; ACUTE ASTHMA OR EXCERISE ASTHMA, COPD, PREMATURE LABOR
    • ROUTE; PO, SC, IV, INHALE (PREFERRED)
    • SE; TEMOR (B2), UP HR (DT VASODIL REFLEX), UP GLUCOSE K, LOW MAG, ALL LUNG OPEN EVEN WITH NOT ALL IS PERFUSED
    • MEDS
    • ALBUTEROL
    • LEVOALBUTEROL
    • BILOTEROL
    • TERBUTALINE
    • METAPROTERENOL
  27. SOMATIC NERVOUS SYSTEM
    CONTROL MUSCLES (VOLUNTARY)
  28. WHAT DOES B1 B2 A1 AND A2 PRIMARLY WORK ON
    • B1 HEART
    • B2 LUNGS
    • A1 VASCULAR SYSTEM
    • A2 NEG FEEDBACK LOOP
  29. EFFECTS OF SYMPATHOMIMETICS
    • VASOCONSTRICTION
    • VASODILATION (SKELETAL MUSCLE)
    • BRONCHDILATION
    • UP HR CONTRACTILITY
    • FREE FATTY ACID
    • GLYCOGENOLYSIS
    • CNS STIMULATION
    • MODULATION OF INSULIN, RENIN, AND PIT HORMONES
  30. NE
    SITES
    • A +++
    • B1++
    • B2 0
    • CO -
    • HR -
    • PVR +++
    • RENAL ---
    • MAP +++
    • AIR RES NC
    • CNS NO
    • GTT 1-16 MCG/MIN

    DIRECT
  31. EPI
    SITES
    • A +
    • B1 ++
    • B2++
    • CO++
    • HR ++
    • PVR +
    • RENAL --
    • MAP +
    • AIR RES--
    • CNS+
    • BOLUS 2-8 MCG
    • GTT 1-20 MCG/MIN
    • DIRECT
  32. DOPAMINE
    SITES
    • A ++
    • B1++
    • B2+
    • CO +++
    • HR+
    • PVR +
    • RENAL +++
    • MAP +
    • AIR RES NC
    • CNS -
    • GET 2- 20 MCG/KG/ MIN
    • DIRECT
  33. ISOPROTERENOL
    SITES
    • A O
    • B1 +++
    • B2 +++
    • CO +++
    • HR +++
    • PVR --
    • RENAL -
    • MAP +-
    • AIR RES ---
    • CNS +
    • BOLUS 1-4 MCG
    • GET 1-5 MCH/ MIN
  34. EPHEDRINE
    SITES
    • A ++
    • B1 +
    • B2 +
    • CO ++
    • HR++
    • PVR+
    • RENAL--
    • MAP++
    • AIR RES --
    • CNS +
    • BOLUS 10-25 MCG
  35. PHENYLEPHRINE
    SITES
    • A+++
    • B1 0
    • B2 0
    • CO -
    • HR-
    • PVR+++
    • RENAL---
    • MAP+++
    • AIR RES NC
    • CNS NO
    • BOLUS 50-100MCG
    • GTT 20-50 MCG/MIN
    • DIRECT
  36. METABOLISM OF SYNTHENTIC NON CATECHOLAMINES
    • NO COMT
    • ALL MAO
    • SLOWER (THUS LONGER LASTING)
  37. METABOLISM OF CATECHOLAMINES
    • INACTIVATED BY
    • MONOAMNINE OXIDASE
    • CATECHOL-O-MEHTYLTRANSFERASE
    • IN LIVER, GI, RENAL
    • MAO RECYCLE OR UPTAKE IN POSTGANG ENDINGS
  38. EPI
    • B1 B2 AGONIST
    • C USE; LOW SYSTEM ABSORBATION OF LOCAL ANEST, ALLERGIC RX, CPR, UP MYOCONTRACTILITY
    • CARDIO; 1-2 MCG/MIN VASODIL, BETA2 AT 4 MCG, 10-20 MCG A AND B WITH A PREDOMINATION (VASOCONSTRICTION, LOW DP, NC WITH MAP, UP HR CO, LOW BLOOD FLOW TO SKIN, MUCOSA, RENAL, LIVER AND DILATION OF MUSCLE, UP RENIN RELAX OF LUNG S. MUSCLE
    • OTHER EFFECTS; UP GLUCOSE, LOW INSULIN K, MYDRIASIS, UP COAGULATION, RELAX GI S. MUSCLE
  39. NE
    • ENDOGENOUS NT A, B1 AND LITTLE B2
    • CARDIO' 4-16 MCG/MIN UP SBP DBP MAP, LOW HR BLOOD FLOW TO RENAL SKIN LIVER, LOW VENOUS RETURN TO LOW CO, LOW PERFUSION =M ACIDOSIS
  40. DOPAMINE
    • D1 D2 (D2 N/V) D1 VASOCON
    • C USE' 0.5-3 D1 UP RENAL PERFUSION, 3-10 BETA2 UP HR, 10 AND UP PERIPHERAL VASOCON UP HR CONTRACTILITY, URINARY OUT, UP NA EXCRETION

    • CARDIO; UP HR SBP SVR
    • OTHER EFFECTS; SOME NE RELEASE, WORKS WELL WITH DOUTAMINE.
    • INTERFERS WITH ART HYPOXIA RESPONES THUS LOW ABG, HYPERGLYCEMIA
  41. DOBUTAMINE
    • B1 GTT 2-10
    • C USE; UP CO
    • CARDIO; DOSE DEPENDANT UP CO WITH ATRIAL FILLING, SMALL UP HR UP RENAL DT UP CO. HIGH DOSE WILL UP HR AND DYSRHTHEMA
  42. ISOPROTERENOL
    • B1 B2 NO A NEED GTT
    • C USE; BRONCHODIL, UP HR 1-5 FOR HEART BLOCK, TX PUL HTN
    • CARDIO; 1-5 UP HR CONTRACTILITY AUTMATICITY CO SBP. LOW MAP SVR DBP CORNARY BLOOD 02= UP ISCHEMIA
  43. EPHEDRINE
    • INDIRECT A AND B RELEASE OF NE
    • C USE LONGER EFFECT 10-25 MG IV FOR JUP HR CO SBP DBP FLOW TO HEART AND MUSCLE CONTRACTILITY. LOW RENAL AND SPLENCHIC FLOW, PO FOR BRONCHIAL ASTHMA, DECONGESTION, 0.5 MG FOR NV. OK FOR PREGO USE NO CHANGE IN UTERIN BLOOD FLOW.
    • 2ND DOSE NOT AS EFFECTIVE
  44. PHENYLEPHRINE
    • MOST A1 AGONIST SOME B
    • C USE. 50-200 FOR BP LOW HR CO BUT INCREASE HEART PERFUSION DECONGESTION, PROLONG SPINAL

    CARDIO UP BE BUT LOW CO DT LOW HR FROM BARO REFLEX. INCREASE ACTION WHEN CLONIDINE IS TAKEN, LOW BLOOD FLOW TO LIVER, RENAL, SKIN, SPLANHIC, UP PUL ART PRESSURE
  45. SIDE EFFECTS OF BETA BLOCKERS
    • DEPEND ON ISA
    • LOW HR, CO, BP CONTRACT
    • ALTER AIRWAY RESISTANCE, CARB AND LIPID META
    • LETHARGY AND VIVID DREAMS. MEMORY LOSS, CROSS PLACENTA
    • UPREGULATE
  46. CONTRAINDINCATION AND WARNINGS
    • CONTRAN
    • SB, H BLOCK UNCOM CHF, CARDIO SHOCK, HYPERSEN TO BETA BLOCKER

    • WARNINGS
    • HYPER ACTIVE AIRWAY, DM, HYPOCLUYCEMIA, ESRD
  47. TREATMENT OF BETA BLOCKER OD
    • ATROPINE 7 MCG/KG
    • ISOPRTERENOL 2-25 MCG/KG
    • PURE B1 TRY DOUBTAMINE
    • GLUCAGON 1-10 MG THEN 5 MG/HR GTT
    • CA CL 250-1000 MG IV
  48. USES OF BETA BLOCKERS
    HTN, ANGINA, POST MI, PREOP HYPOTHYROIDISM, CARDIO DYSRHYTHMIAS, HF
  49. LABETALOL
    • BLOCK A1 B1 B2
    • MORE BETA POTENT THAN ALPHA
    • CARDIO; LOW BP SVR, NO CHANGE TO CO
    • TX; HTN, EPI OD, ANGINA,
    • SE O BP, BRONCHOSPASMS, HEARTBLOCK, FLUID RETENTION
  50. Carvedilol
    • A1 B1 B2
    • FOR CHF LOW BP MED TO SERVER
    • ADD ON TX
    • FOR HF START 3.125 MG BID TO 50
    • FOR BP 6.25 BID TO 50
  51. POSTITIVE INOTROPIC DRUGS
    • CARDIO GLYCOSIDES
    • DIG, DIGITOXIN, OUABAIN

    • NONGLYCOSIDES
    • PDE INHIBITOR (MIDRINONE, INAMRINONE)
    • CA
    • GLUCAGON
  52. DIGOXIN
    • MECH; 1. BLOCK NA/K ATP PUMP THUS UP NA THUS UP INTRACELL CA IONS 2. ENHANCE PSN ACTIVITY THAN LOW SA NODE(VAGAL TONE)
    • C USE; TX HF AND SLOW VENT RATE, IMPROVE S/S OF HR, CONTROL RATE OF HR WITH SUPERVENT ARRHYTHMIAS, LOW DEATH IN HR BUT UP IN CARDIAC DEATH
    • CARDIO; UP CONTRACTILITY STROKE VOL, LOW HEART SIZE LVDEP. UP CO AND PERFUSION TO KIDNEYS TO EXCRETE EXCESS FLUID
    • PROLING P-R INTERVAL, SHORTEN Q-T, LOW STAGE 3 DEPOL DIM T WAVE
  53. PHARMACOKINETICS OF DIG
    • ABSORD 75% PO
    • RAPID THERAPY INDEX VIA IV
    • NONO TO IM
    • 35% EXCRETED BY URINE DAILY
    • T.5 31-35 HOURS, 4.4 DAY IN ESRD
    • CLCR 10-50 (25-75%) LESS THAN 10 (10-25% OF DOSE)
    • 15-30 TIME HIGH CONCENTRATION IN HEART AND HALF THAT IN MUSCLE
    • 25% PROTEIN
  54. DIG RANGES
    • CHF .2-.8
    • ARRHYTHMIAS 1.5-2.5
    • TOXIC OAVE 2.5
    • TACH COMMON OVER 2
    • MEASURE THROUGH (8 HOURS)
  55. CONTRAN/WARNINGS OF DIG
    • CON
    • AV BLOCK
    • CONSTRICTIVE PERICARDITIS
    • IDIOPATHIC HYPERTHRPOPHIC SUBAORTIC STENOSIS\

    WARNINGS

    • HYPOXIA WPW
    • MYXEDMA SSS
    • INCOMPLETE AV BLOCK ESRD
    • ACUTE MI ELDERLY
    • SERVERE PUL DISEASE
  56. INTERACTIONS WITH DIG
    • ENEZYM INDUCTORS AND INHIBITORS
    • INCREASE SERUM K
    • INCREASE ARRHYTHMIAS WITH UP CA LOW K AND MAG
  57. DIG TOXICITY
    DT ELECTROLYTES, RENAL FUNCTION, HYPOXEMIA,

    • LEVELS .5-2.5
    • KIDS MORE TOLERANT

    S/S NV ANOREXIA, VISUAL DISTERBANCE AND PAIN FOR NEURALGIA, V FIB ATRIAL TACHY WITH BLOCK
  58. INOTROPE
    BASED ON CONTRACTION
  59. DROMOTROP
    CONDUCTION OF AV NODE
  60. CROMOTROP
    CHANGE OF HR
  61. TREATMENT OF DIG TOXICITY
    • ONE TIME USE OF DIGOXIN IMMUNE FAB (DIGIBIND)
    • BIND WITH KIDNEYS EXCRETED
    • COST $$$ GIVE FOR 1 DIG ARRHYTHMIAS, ACUTE OD 10 MG OR MORE, K OF 5 OR HIGHER
    • NOTE SURE REPLACE K BUT BE CAREFUL
    • TEST IF ARRHYTHMIAS UNREPSONIVE TO K THEN TRY PHENYTOIN OR LIDIOCAINE
    • AVOID EPI, DOBUTAMINE, DOP
  62. DIGITOXIN, OUABAIN
    DIGITOXIN LONG TERM DIG, HALF LIFE 5-7 DAYS

    OUABAIN SHORT ACTING IV ONLY NO ADVANTAGE OVER DIG IV
  63. SELECTIVE PHOPHODIESTERASE (PDE) INHIBITORS
    • INHIBIT ISOENXYME FRACTION PDEIII UP CO AND VASODIL
    • SLOW HYDROLYSIS OF cAMP THUS UP INTRA CELL THUS UP CA IN CELL= INOTROPIC
    • LONG ACTING DOBUTAMINE
    • BYPASS BETA BLOCKERS
    • CAN USE WITH CATECHOLAMINE, DIG (WITHOUT UP CHANCE OF TOXICITY)
    • USE FOR PT WITH ACUTE HR (MI) OD ON BETA BLOCKERS
  64. INAMRINONE
    • PDE III
    • POSTIVIE INOTRPIC AND VASODIL
    • LOW LVEDP, BP
    • UP HR UP CO
    • LOW CHANCE OF ARR
    • SE LOW BP, THROMBOCYTOPENIA,
    • DOSE HIGH THERE WINDOW
    • .75 MGKG OVER 2-3 MINS THEN 5-10 MCG GTT MAY REPENT BOLUS IN 30 MINS
    • LOOK FOR KIDNEYS (75% DOSE)
  65. MILRINONE
    • PDE III
    • POSTIVE INOTROPIC VASODIL
    • FOR ACUTE L VENT DYSFUNCTIONS
    • T.5 2.7 HOURS WITH EXCRETED URINE UNCHANGED
    • DOSE 50 MCGKG BOLUS WITH .5 MCG KGMIN GTT
    • LOOK FOR KIDNEY
    • SE VENT ARR, ANGINA, LOW BP, HA
  66. THEPHYLLINE
    • NONPHOSHPDIESTERASE INHIITOR
    • TX BRONCHSPASMS (NOW ITH B2 ANGONIST AND STEROIDS DON'T WORK
    • REVERSE STRESS TEST WITH ADENOSINE
    • NEONATE FOR APENA
    • NARROW WINDOW 6-8 OVER ARR
  67. PHENTOXIFYLLINE
    • INCREASE FLEXIBLITY OF ERTHROCYTES AND LOW VISCOSITY OF BLOOD, IMPROVING BLOOD FLOW
    • USED IN CLAUDICATION DT OCCLUSIVE DISEAASE OF LIMBS
    • SE LOW BP, ANGINA, ARR
    • INCREASE BLEEDING
  68. CALCIUM
    • IV LAST 10-20 MINS INCREASE STROKE VOL, AND LVEDP
    • LOW SVR HR
    • STABLIZE CELL MEMBRANE FOR HYPER K
    • 5-10 MG KG IVE BOLUS
    • LOOK FOR LOW CA WITH
    • CARDIOPASS SOLUTION
    • WHOLE BLOOD TRANSFUSION
    • META ACIDOSIS WITH BICARB
  69. GLUCAGON
    • HORMONE IV, SQ OR IM
    • ENHANCE PRODUCTION OF cAMP NO BETA RELEASE CATECHOLAMINES
    • INCREASE HEART CONTRACTIY
    • IV 1-5 MG THEN 20 MGHR GG
    • CAN GET UP HR MAP NONE SVR
    • SHORT TERM
    • SE NV HYPER SUGAR, HYPO K, CAN CAUSE HTN
  70. Phenyalkylamine
    • binds to the intracelluar portion of the ltype channel
    • Verapamil
    • block Ca channels to the av node
    • class 4 antiarrythmics
  71. Dihydropyridines
    • med nifedipine, amiodipine, felodipine, isradapine, nicardipine, nimodipine, celvidipine
    • for angina and htn
  72. Ca blocker
    • low heart contract, HR, SA NODE CONDUCT, RELAX VASCO SMOOTH MUSCLE THUS LOW BP
    • RISK OF CHRONIC TX GI BLEEDING, CANCER
  73. VERAPAMIL
    • PHENYLALKYLAMINE
    • TX SUPRAVENT TACH(AT AV NODE), ANGINA, HTN, PREMATURE LABOR, MAY LOWER UTERINE FLOW
    • PK; COMPLETELY ABSORBED PO, HIGH FIRST PASS, T.5 6-12 HOURS, WACTH KIDNEY FX
    • SE DEPRESS AV NODE, NEG CHRONOTROPIC, INOTROPC EFFECTS,
  74. DILTIAZEM
    • BENZOTHIAZEPINES
    • BLOCK CA AT AV NODE (1ST LINE AGENT FOR SUPRAVENT TACHYARR
    • TX AFIB/FLUTTER, ANGINA, HTN
  75. NIFEDIPINE
    • DIHYDROPYRIDINE
    • DIL CORNARIES AND PERPHERAL BETTER THAN VERAPAMIL
    • LITTLE TO NO DEPRESSION OF SA AV NODE
    • DCREASE IN BP MAY LEAD TO REFLEX TACHYCARDIA
    • DOSE 10-20 PO 3X DAY
    • SE LEAD TO CEREBROVASCULAR EDEMA, MI, LOW BP
  76. NICARDIPINE
    • DIHYROPYRIDINE
    • LACK SA AND AV EFFECTS
    • GREASTEST VASODIL OF ALL CCB,
    • PO OR IV
    • SIMILAR TO NIFEDIPINE
  77. CELVIDPINE
    • DIHYDROPYRIDINE
    • INJECTABLE
    • NOT AVAILABLE NOW
    • TX HTN
    • ONSET 2-4 MIN
    • DURATION IV 5-15 MIN
    • DISTRIBUTION 0.17 L/KG
    • 99.5% PROTEIN BOUND
    • META BY ESTERASES
    • T.5 1 MIN AND TOTAL OUT 15 MIN
    • WARNINGS HYPO BP, REBOUND HTN, REFLEX TACHYCARDIA
    • MAX DOSE 16 MG/HR
    • INTIAL DOSE 1-2 MG/HR
    • DOUBLE DOSE TILL WANTED BP IS REACHED
  78. NIMODIPINE
    • DIHYDROPYRIDINE
    • HIGHLY LIPID-SOLUBLE, GOES IN TO CNS
    • FOR CEREBRAL VASOSPASMS
    • DOES .7 MG/KG INITIALLY THEN .35 MG/KG Q 4 HOURS FOR 21 DAYS
    • INTERACTIONS; ANESTHETIC DRUGS, VERAPAMIL

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