For muscarinic recepters M1,M2,and M3. Where are they located?
What is there mechanism of action?
M1---CNS, Ganglia and GI--- PLC/IP3--- increase in Ca
M2--- Heart--- inhibits Adenyl Cyclase--- K leaving cell
M3--- Smoooth Muscle, BV, Eye, Sweat and lacrimal glands--- PLC/IP3--- increase in Ca
note: respiratory, GI and bladder are M1/3
Name the Cholinergic agonists. (MCBCP)
Which are Susceptable to Cholinesterase?
What is the Function of AntiCholinesterases?
what are the two types?
They inhibit the enzyme Acetylcholinesterase, thus decreasing the breakdown of ACh, prolonging its existance.
Name the irreversible Anti-ChE agents.
What is the group called?
Parathion, Malathion, Diazinon
Called Organophospherous compounds
Name the Reversible Anti-ChE.
Which are short acting and which are Medium acting?
Edrophonium--- Short (5-10 mins)
What are some nerve gas poisons? (SST)
Soman, Sarin, Tabun
What is the Problem in Myasthenia Gravis?
What drugs are used in Myasthenia Gravis?
It is an autoimmune disorder, in which weakness is caused by circulating antibodies that block acetylcholine receptors at the post-synaptic neuromuscular junction,inhibiting the stimulative effect of the neurotransmitter acetylcholine.