What process is undergone in order to secrete proteins into the host cells of Enteropathogenic E. Coli (EPEC)?
TTSS initiates the secretion of proteins into the host cell. Tir inserts into the epithelial cell and functions as receptor for the outer membrane adhesin, intimin. The intimin-Tir binding results in the polymerization of actin and the accumulation of cytoskeletal elements beneath the attached bacteria. The cell then loses surface integrity and dies