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What is primary gout?
increased production of uric acid
what is secondary gout?
decreased excretion of monosodium urate
What are some symptoms of hypouricemia?
What enzyme deficiency results in hyperuricemia?
What enzyme is related to Lesch Nyhan syndrome?
what enzyme can undergo and overreactive mutation and produce hyperuricemia?
PRPP synthetase (produces too many purine nucleotides)
What is the recommended treatment for secondary gout?
uricosuric agents, increase renal clearance of uric acid by inhibiting reabsorption of urate
What is the main treatment for primary gout?
allopurinol, suicide inhibitor, similar to hypoxanthine and used as a substrate by xanthine oxidase
what are the products formed when allopurinol is used?
xanthine and hypoxanthine
what drug is given to prevent tumor lysis syndrome?
rasburicase, converts uric acid to water-soluble products
lecture 46 hyperuricemia