Lecture 47.txt

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Author:
cjharmon311
ID:
44723
Filename:
Lecture 47.txt
Updated:
2010-10-25 00:48:47
Tags:
Lecture
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Description:
Lecture 47 pyrimidine biosynthesis
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  1. What accumulates in adenosine deaminase (ADA) deficiency?
    • adenosine, which leads to accumulation of dATP (inhibitor off ribonucleotide reductase)
    • produces general deficienct of dNTPs leading to an ineffective immune system
  2. What is methotrexate a analog to?
    folate, competetive inhibitor for dihydrofolate reductase, lack of tetrahydrofolate inhibits thymidylate synthase
  3. What is AZT used to treat and what does it compete with?
    HIV, it competes with dTTP inhibiting DNA replication
  4. What does trimethoprim inhibit?
    bacterial dihydrofolate reductase, inhibiting bacterial growth

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