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cjharmon311
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What accumulates in adenosine deaminase (ADA) deficiency?
- adenosine, which leads to accumulation of dATP (inhibitor off ribonucleotide reductase)
- produces general deficienct of dNTPs leading to an ineffective immune system
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What is methotrexate a analog to?
folate, competetive inhibitor for dihydrofolate reductase, lack of tetrahydrofolate inhibits thymidylate synthase
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What is AZT used to treat and what does it compete with?
HIV, it competes with dTTP inhibiting DNA replication
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What does trimethoprim inhibit?
bacterial dihydrofolate reductase, inhibiting bacterial growth
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