This refers to the repair process involved when there is sufficient loss of tissue to prevent coaptation of the wound margins (abscesses, ulcers, infarctions, etc.). Generally, there is extensive inflammatory exudate and necrotic debris that must be removed before healing can occur. In this
situation, there is a slow, gradual buildup of granulation tissue beginning at the margins of the wound and growing inward at a rate of approximately 0.1 - 0.2 mm/day. The exposed granulation tissue is subject to trauma, and due to the delicate nature of the newly formed capillaries, is prone to bleed. Migration of surface epithelium can progress only so far as the underlying granulation tissue and therefore it takes longer for the wound to be isolated from the surrounding environment increasing the likelihood of infection. Wound contraction occurs in this.
Healing by Second Intention (Secondary Union)