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alters perception to pain
slowed gastric emptying
respiratory depression (?)
What distributive property accounts for the speed of onset of Fentanyl?
What distributive property accounts for the speed of onset of Sufentanil?
What distributive property accounts for the speed of onset of Alfentanil?
What do we know about morphine from it's distributive properties?
slow passage across BBB
slow onset and long duration of action
What do Fentanyl and Sufentanil's distributive properties tell us about how they work?
Very high lipid solubility means a rapid onset and short duration of action.
High lipid solubility also increases first pass effect in lungs
What do alfentanil's distributive properties tell us about how it works?
highly nonionized allows it to cross the BBB so rapid acting.
small Vd due to PRO binding allows for quick redistribution of alfentanil
Which opioids metabolize to active metabolites?
Meperidine=Normeperidine which is CNS excitatory
Morphine=Morphine 6 glucuronide which is more potent and longer lasting than morphine
Which opioid is metabolised through ester hydrolysis?
Which opioids should be avoided in renal patients?
Morphine and Meperedine due to their active metabolites.
What causes muscle rigidity?
High does, especially fentanyl and it's derivatives.
What is the area stimulated to cause miosis?
Opioid flash cards