Dosage forms Exam 1 solubilizing

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Author:
swynocker
ID:
45377
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Dosage forms Exam 1 solubilizing
Updated:
2010-10-27 02:11:12
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Dosage forms exam solubilizing
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Solubilizing
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  1. What can be added to adjust pH to optimize drug solubility
    Buffer
  2. Manufactures commonly add ____ and _____ to adjust pH
    Strong Acids and Bases (HCl, NaOH)
  3. Examples of cosolvents that are FDA approved
    ethanol, glycerin, propylene glycol, polyethylene glycol
  4. Cosolvents are usually blended with _____ to achieve optimal polarity
    Water

    • Ethanol 2-40% usually
    • 98% to reconstitute carmustine
  5. surfactants are_______ molecules and have tendency to accumulate (absorb) at the interface between two phases.
    Ampiphilic
  6. Hydrophilic head can be:
    anionic, cationic, amphoteric, or nonionic group (least toxic)
  7. Surfactants have two phases
    Air/water and Water/oil
  8. Surfactants form ____ at critical concentration
    Micelle
  9. In the core of the micelle, surfactants help ______ drugs.
    Solubilize
  10. Surfactant types are:
    • Anionic- SDS, docusate sodium
    • Cationic- Benzalkonium chloride
    • Nonionic- Polysorbate 80/20
  11. Cyclodextrins
    Monomolecular compounds composed of a ring of 6-8 glucose units
  12. T/F It is within the cavity that the poorly soluble molecule is solubilized by the Cyclodextrin host.
    True!

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