NC-Antiretrovirals.txt

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Anonymous
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45481
Filename:
NC-Antiretrovirals.txt
Updated:
2010-10-27 15:58:59
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antiretro
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antiretro
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  1. NRTI Class AE, SC
    • Lactic Acidosis w/Hepatic Stenosis
    • Renal Adj (ex ABC) when GFR <60ml/min
    • Don't act through CYP
  2. zidovudine
    • NRTI
    • Retrovir (AZT)
    • 1) BMSup
    • 2) Anemia
    • 3) Fatigue, myalsia
    • DI: antag w/d4t
  3. didanosine
    • Videx (ddi)
    • 1) pancreatitis
    • 2) peripheral neuropathy
    • DI: TDF increases Conc
    • SC: WBD - usually empty stomach (w/TDF w/food)
  4. Stavudine
    • (Zerit) (D4t)
    • 1) Lipoatrophy
    • 2) Hyperlipidemia
    • DI: AZT
    • SC: Fallen out of favor - weight based dosing
  5. Lamivudine
    • (Epivir) (FTC)
    • hyperpig of palms & soles
    • don't combine
    • similar
    • HEPB activity
  6. Abacavir (Ziagen, ABC)
    • 1) risk of MI
    • 2) hypersensativity
    • SC: no renal adj
  7. Tenofavir
    • Viread (TDF)
    • preferred
    • 1) nephrotox
    • 2) GI, flatulence
    • DI: ddI & ATV
    • SC: Activity vs. HBV
  8. NNRTI Class effects
    • AE: Rash & Hepatotox
    • DI: Impact CYPsystem
    • SC: lower genetic barrier to resistance
  9. Nevirapine
    • (Viramune, NVP)
    • not for: men CD4>400
    • women CDR>250
    • DI: metal by 3A4, cyp inducer
    • SC: dose titrate to start
  10. Efavirenz
    • (Sustiva) (EFV)
    • 1) CNS - dreams
    • DI: mixed CYP inh/ind
    • Food inc conc - Empty Stomach
    • SC: teratogenicity, false positive cannaboid test
  11. Delaviridine
    • (Rescriptor, DLV)
    • Fallen out of face - less potent, more frequent dosing
  12. Ertavirine
    • (Intelence, ETR)
    • AEL GI
    • mostly for resistance
    • with food, BID dosing
    • induces 3a4, inhibit 2c9
  13. Raltegravir
    • (Isentresss, RAL)
    • AE: GI, HA, ELevations in CPK
    • DI: dec by rif
    • SC: BID dosing, hep metal, gen well tolerated
  14. PI CLass
    • Higher barrier to resistance
    • hep metab - no renal adj
    • Lipid changes, Insulin resistance, elevated transminases, GI upset, bleeding in hemos
    • DI: all metal by 3a4, all induce 3a4
    • most with food
  15. Ritonavir
    • (Norvir, RTV)
    • taste, paresthesias, hepatits
    • **DOSING - tabs - NO REFRID)
  16. Indinavir
    • (Crixivan, IDV)
    • Nepprholithiasis, hyperbilli
    • ES (unboosted)
  17. Nelfinavir
    • (VIracept, NFV)
    • Diarrhea
  18. Kaletra
    • Lopinavir/Ritonavir - KTA
    • N/D, panc - tab - no food & fridge
  19. Atazanavir
    • (Reyataz, ATV)
    • Hyperbilli, ATC, nephrolithiasis
    • DDIs: acid sup, TDF
  20. Fosamprenavir
    • Rash, paresthesias
    • Sulfa caution
    • w/ or w/o food
  21. Tipranavir
    • (Aptivus, TPV)
    • Hepatitis, rash, ICH
    • Sulf caution
  22. Darunavir
    • (Prezista, DRV)
    • Rash - Sulfa - Caution
    • preferred
  23. Combivir
    Lamivudine & Zidovudine
  24. Trizivir
    Lamivudine, Zidovudine, Abacavir
  25. Epzicom
    Lamivudine & Abacavir
  26. Truvada
    Emtricitabine & Tenofovir
  27. Atripla
    Emtricitabine & Tenofavir & EFA

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