Card Set Information
How does HIV cause reduced CD4+ T cells?
Direct HIV-mediated destruction of CD4 T lymphocytes (explained beneath)
Autoimmune destruction of CD4 T lymphocytes
Toxicity of viral proteins to CD4 T lymphocytes + marrow suppresstion
Induction of apoptosis
How is HIV diagnosed?
ELISA + Western blot
: presence of anti-p24 and anti-gp120
: CD4:CD8 ratio, viral load, B2 microglobulin
Name 6 classes of drugs for HIV.
Nucleoside reverse transcriptase inhibitors (NRTI)
Non-nucleoside reverse transcriptase inhibitors (NNRTI)
Cellular chemokine receptor antagonists
Therapy should involve combination of drugs
: all NNRTI's interacts with other drugs
What are some infections commonly occuring in HIV patients?
: CMV, HSC, TB, strep pneumo, H.I, mycobacterium avium, cryptococcus
: NM, HSC, cryptococcus
: cryptosporidium, m.avium, candida
: pneumocystis carinii, m.avium
Name 5 non-infection caused illnesses in HIV patients.
Thrombocytopenia & bruising