MED-Glucagon

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Author:
amerelman
ID:
46229
Filename:
MED-Glucagon
Updated:
2010-10-31 09:26:31
Tags:
MED Glucagon
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Description:
MED-Glucagon
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  1. Functional Class
    Hormone
  2. Mechanism of Action
    • Protein secreted by alpha cells of the Islets of Langerhans in the pancreas
    • Converts stored glycogen in the liver to glucose
    • Inhibits synthesis of glycogen from glucose
    • Enhances conventional treatments for Ca channel blocker and beta-blocker OD by producing positive inotropic and chronotropic effects on the heart via stimulation of glucagon receptors in the myocardium
  3. Indications
    • Hypoglycemia without IV access
    • Adjuvant treatment of toxic effects of Ca channel blockers and beta-blockers
  4. Contraindications
    Hypersensitivity
  5. Precautions
    Only effective if there are sufficient stores of glycogen in the liver
  6. Side Effects
    • Hypotension
    • Headache
    • Dizziness
    • N/V
    • Hyperglycemia
    • Hypokalemia
  7. Interactions
    None
  8. Dosage and Route
    • Adult:
    • Hypoglycemia: 1 mg (unit) IM/SC q 10-20 mins
    • CCB/Beta blocker OD: 2-5 mg IM/SC/IV

    • Pedi:
    • 0.01-0.1 mg/kg IM/SC
  9. Pharmacokinetics
    • Onset: 5-20 mins
    • Duration: 1-1.5 hours

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