TB Rx

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Author:
Anonymous
ID:
46298
Filename:
TB Rx
Updated:
2010-10-31 15:51:24
Tags:
svetik TB Rx
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Description:
TB Rx svetol
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  1. INH
    Name, MoA, MoR, Adverse side effects
    • Isoniazid: .
    • Mechanism of Action: Inhibition of mycolic acid synthesis
    • Resistance: Lose catalase & peroxidase needed to activate prodrug
    • Adverse side effects: hepatotoxicity, neurotoxicity
  2. RIF
    Name, MoA, MoR, Adverse side effects
    • Rifampin: .
    • Mechanism of Action: Inhibition of RNA synthesis
    • Resistance: Albeted beta subunit or RNA polymerase
    • Adverse effects: .
    • HEPATOXICITY
    • HYPERSENSITIVITY
    • RED STAINING (CONTACTS TOO)
    • POTENT CYP 450 INDUCTION
  3. PZA
    Name, MoA, MoR, Adverse side effects
    • Pyrazinamide: .
    • Mechanism of action: Depletion of membrane energy
    • Resistance: Lose pyrazinaminidase - nicotinamidase activity (no prodrug activation)
    • Adverse effects: .
    • HEPATOTOXICITY
    • GOUT
    • PHOTOSENSITIVITY
    • not indicated in pregnancy
  4. EMB
    Name, MoA, MoR, Adverse side effects
    • Ethambutol: .
    • Mechanism of Action: Inhibition of arabinogalactan synthesis
    • Resistance: Mutation in gene controlling inhibitor(s)
    • Adverse effects: .
    • RETROBULBAR NEURITIS
    • PERIPHERAL NEUROPATHY
    • HYPERURICEMIA

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