Lecture 56.txt

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Lecture 56.txt
2010-11-06 15:10:50
Biochemistry Eye

Biochemistry of the Eye
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  1. what is the major metabolic fuel for the eye?
  2. what do retinol and retinoic acid prevent in the cornea?
    the synthesis of keratin
  3. what is the use of retinyl phosphate in the cornea?
    it is required for the production of glycoproteins
  4. what is the path of the aqueous humor after it is procuded by the ciliary process?
    enters posterior chamber --> flows through pupil into anterior chamber --> drained through trabecular meshwork--> leaves via Schlemm's canal
  5. what forms the blood aqueous barrier?
    tigh junctions between nonpigmented epithelium (NPE) and nonleaky enothelial cells of iris capillaries
  6. what is the photoreceptor pigment in rod cells?
    rhodopsin (opsin and 11-cis-retinal)
  7. what are the photoreceptor pigments in cone cells?
    red, green or blue pigment
  8. what is the function of cones in the retina?
    sensing/seeing color and acute vision
  9. what is the function of rods in the retina?
    sensing/seeing night and peripheral vision
  10. when are the photoreceptors depolarized?
    in the resting state/dark-adapted state
  11. when are the photoreceptors hyperpolarizes?
    in the activated state/light-excited state
  12. in what 3 ways is lutein and zeaxanthine believed to prevent AMD?
    • 1. filtering out blue light
    • 2. protect photoreceptors from oxidation
    • 3. protect blood vessels supplying the macular region