NERVOUS SYSTEM I FINAL EXAM DRUGS

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NERVOUS SYSTEM I FINAL EXAM DRUGS
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2010-11-07 19:55:52
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NERVOUS SYSTEM FINAL EXAM DRUGS
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NERVOUS SYSTEM I FINAL EXAM DRUGS
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  1. CHLORPROMAZINE
    1ST GENERATION ANTIPSYCHOTIC

    THORAZINE
  2. MESORIDAZINE
    1ST GENERATION ANTIPSYCHOTIC

    SERENTIL
  3. THIORIDAZINE
    1ST GENERATION ANTIPSYCHOTIC

    MELLARIL
  4. FLUPHENAZINE
    1ST GENERATION ANTIPSYCHOTIC

    PROLIXIN
  5. PERPHENAZINE
    1ST GENERATION ANTIPSYCHOTIC

    TRILAFON
  6. TRIFLUOPERAZINE
    1ST GENERATION ANTIPSYCHOTIC

    STELAZINE
  7. THIOTHIXENE
    1ST GENERATION ANTIPSYCHOTIC

    NAVANE
  8. HALOPERIDOL
    1ST GENERATION ANTIPSYCHOTIC

    HALDOL
  9. LOXAPINE
    1ST GENERATION ANTIPSYCHOTIC ACCORDING TO SYLLABUS AND LEXICOMP, BUT 2ND GEN ACCORDING TO MONIRI AND BY LOOKING AT THE STRUCTURE

    LOXITANE
  10. MOLINDONE
    1ST GENERATION ANTIPSYCHOTIC

    MOBAN
  11. CLOZAPINE
    2ND GENERATION ANTIPSYCHOTIC

    CLOZARIL
  12. RISPERIDONE
    2ND GENERATION ANTIPSYCHOTIC

    RISPERDAL
  13. OLANZAPINE
    2ND GENERATION ANTIPSYCHOTIC

    ZYPREXA
  14. QUETIAPINE
    2ND GENERATION ANTIPSYCHOTIC

    SEROQUEL
  15. ZIPRASIDONE
    2ND GENERATION ANTIPSYCHOTIC

    GEODON
  16. ARIPIPRAZOLE
    2ND GENERATION ANTIPSYCHOTIC

    ABILIFY
  17. PALIPERIDONE
    2ND GENERATION ANTIPSYCHOTIC

    INVEGA
  18. ILOPERIDONE
    2ND GENERATION ANTIPSYCHOTIC

    FANAPT
  19. ASENAPINE
    2ND GENERATION ANTIPSYCHOTIC

    SAPHRIS
  20. PHENYTOIN
    HYDANTOIN ANTIEPILEPTIC

    DILANTIN
  21. PHENOBARBITAL
    BARBITURATE ANTIEPILEPTIC

    LUMINAL
  22. PRIMIDONE
    ANTIEPILEPTIC

    • NA+ CHANNEL BLOCKER
    • METABOLIZED INTO PHENOBARBITAL, WHICH IS THEN ALSO ANTIEPILEPTIC BY MANY MORE MECHANISM AS WELL

    MYSOLINE
  23. CARBAMAZEPINE
    IMINOSTILBENE ANTIEPILEPTIC

    TEGRETOL
  24. OXCARBAZEPINE
    IMINOSTILBENE ANTIEPILEPTIC

    TRILEPTAL
  25. ETHOSUXIMIDE
    SUCCINIMIDE ANTIEPILEPTIC

    CA+ CHANNEL BLOCKER, WHICH IS GOOD FOR ABSENCE SEIZURES

    ZARONTIN
  26. VALPROIC ACID
    ANTIEPILEPTIC OR BIPOLAR THERAPY

    NA+ AND CA+ CHANNEL BLOCKER

    DEPAKENE
  27. CLONAZEPAM
    BENZODIAZEPINE ANTIEPILEPTIC

    KLONOPIN
  28. DIAZEPAM
    BENZODIAZEPINE ANTIEPILEPTIC

    VALIUM
  29. LORAZEPAM
    BENZODIAZEPINE ANTIEPILEPTIC

    NO CYP METABOLISM, STRAIGHT TO GLUCURONIDATION

    ATIVAN
  30. GABAPENTIN
    ANTIEPILEPTIC

    NEURONTIN
  31. LAMOTRIGINE
    ANTIEPILEPTIC

    LAMICTAL
  32. LEVETIRACETAM
    ANTIEPILEPTIC

    KEPPRA
  33. TIAGABINE
    ANTIEPILEPTIC

    GABITRIL
  34. TOPIRAMATE
    ANTIEPILEPTIC

    TOPAMAX
  35. FELBAMATE
    ANTIEPILEPTIC

    FELBATOL
  36. ZONISAMIDE
    ANTIEPILEPTIC

    ZONEGRAN
  37. LACOSAMIDE
    ANTIEPILEPTIC

    VIMPAT
  38. L-DOPA
    DOPAMINE PRECURSOR FOR PARKINSON'S

    NOT HIGHLY USEFUL BY ITSELF. CAUSES PERIPHERAL SIDE EFFECTS, AND NOT MUCH CAN CROSS THE BBB WITHOUT BEING METABOLIZED FIRST BY EITHER COMT OR DOPA DECARBOXYLASE (AAD). L-DOPA MUST CROSS THE BBB BEFORE BEING COVERTED TO DOPAMINE SINCE DOPAMINE CANNOT CROSS THE BBB. AFTER BBB CROSSING AND CONVERSION TO DOPAMINE IT CAN STIMULATE MOVEMENT IN THE NIGROSTRIATAL PATHWAY.
  39. L-DOPA + CARBIDOPA
    DOPAMINE PRECURSOR COMBO THERAPY FOR PARKINSON'S

    L-DOPA IS A PRECURSOR TO DOPAMINE, BUT L-DOPA IS ABLE TO CROSS THE BBB WHEN ADMINISTERED (BUT ONLY IN SMALL AMOUNTS BY ITSELF, AND WITH PERIPHERAL SIDE EFFECTS)

    CARBIDOPA IS A DOPA DECARBOXYLASE INHIBITOR THAT BINDS VITAMIN B6 (PYRIDOXINE). VIT B6 IS A NECESSARY COFACTOR TO DOPA DECARBOXYLASE, SO IT NOW CANNOT METABOLIZE L-DOPA TO DOPAMINE IN THE PERIPHERY. REMEMBER ONLY L-DOPA CAN CROSS THE BBB, SO IT MUST STAY L-DOPA UNTIL AFTER BBB CROSSING, AND THEN BE CONVERTED FOR USE IN THE NIGROSTRIATAL PATHWAY.

    SINEMET
  40. CARBIDOPA
    DOPA DECARBOXYLASE (AAD) INHIBITOR ADJUNCT THERAPY FOR PARKINSON'S

    ALLOWS MORE L-DOPA TO CROSS THE BBB, EVEN IN LOWER DOSES, WHICH LOWERS PERIPHERAL SIDE EFFECTS AND STIMULATES MORE MOVEMENT IN THE NIGROSTRIATAL PATHWAY

    LODOSYN
  41. L-DOPA + CARBIDOPA + ENTACAPONE
    DOPAMINE PRECURSOR COMBO THERAPY FOR PARKINSON'S

    L-DOPA CROSSES THE BBB TO BE CONVERTED TO DOPAMINE BY DOPA DECARBOXYLASE (AAD) AND STIMULATE MORE MOVEMENT IN THE NIGROSTRIATAL PATHWAY (ALONE IT IS NOT VERY USEFUL AND SOMEWHAT TOXIC)

    CARBIDOPA IS A DOPA DECARBOXYLASE (AAD) INHIBITOR IN THE PERIPHERY ONLY (WHICH LOWERS PERIPHERAL SIDE EFFECTS AND ALLOWS L-DOPA TO CROSS THE BBB IN GREATER AMOUNTS TO BE CONVERTED TO DOPAMINE FOR THE NIGROSTRIATAL PATHWAY WHERE IT'S NEEDED

    ENTACAPONE IS A COMT INHIBITOR IN THE PERIPHERY ONLY, SO MORE L-DOPA IS ABLE TO CROSS THE BBB AS NEEDED

    STALEVO
  42. SELEGILINE
    • MONOAMINE OXIDASE INHIBITOR
    • FOR PARKINSON'S OR DEPRESSION

    DOES NOT TEND TO CONTRIBUTE TO HYPERTENSIVE CRISIS AS IT DOES NOT INHIBIT MAO-A IN THE GUT

    ELDEPRYL, EMSAM(PATCH)
  43. RASAGILINE
    MAOI USED FOR PARKINSON'S

    LOWERS DOPAMINE CONVERSION TO DOPAC BY MAO-B IN THE BRAIN. THIS LOWERS POTENTIAL FREE RADICAL DAMGE TO SUBSTANTIA NIGRAL DOPAMINERGIC NEURONS, AND SLOWS PROGRESSION OF PARKINS'S DISEASE

    AZILECT
  44. TOLCAPONE
    COMT INHIBITOR FOR PARKINSON'S

    • PERIPHERY AND BRAIN
    • AIDS PROPER USE OF L-DOPA
    • HIGHLY TOXIC AND ONLY A LAST RESORT

    TASMAR
  45. ENTACAPONE
    COMT INHIBITOR FOR PARKINSON'S

    PERIPHERY ONLY, BUT INCREASES AMOUNT OF L-DOPA THAT MAKES IT THROUGH THE BBB TO BE CONVERTED TO DOPAMINE AND UTILIZED TO ADD MOVEMENT IN THE NIGROSTRIATAL PATHWAY

    COMTAN
  46. ROTIGOTINE
    D2 FAMILY RECEPTOR AGONIST FOR PARKINSON'S

    NEUPRO
  47. BROMOCRIPTINE
    D2 FAMILY RECEPTOR AGONIST FOR PARKINSON'S

    PARLODEL
  48. PRAMIPEXOLE
    D2 FAMILY RECEPTOR AGONIST FOR PARKINSON'S

    MIRAPEX
  49. ROPINIROLE
    D2 FAMILY RECEPTOR AGONIST FOR PARKINSON'S

    REQUIP
  50. AMANTADINE
    • DA RECEPTOR AGONIST FOR PARKINSON'S
    • PRIMARILY AN ANTIVIRAL

    WAS THE MODEL USED TO DEVELOP MEMANTINE

    SYMMETREL
  51. BENZTROPINE
    • MUSCARINIC RECEPTOR ANTAGONIST
    • FOR PARKINSON'S

    COGENTIN
  52. DIPHENHYDRAMINE

    (NOT AIMING FOR TYPICAL ANTIHISTAMINE USE HERE)
    • MUSCARINIC RECEPTOR ANTAGONIST
    • FOR PARKINSON'S

    BENADRYL
  53. TRIHEXYPHENIDYL
    • MUSCARINIC RECEPTOR ANTAGONIST
    • FOR PARKINSON'S

    ARTANE
  54. TACRINE
    • ANTICHOLINESTERASE AGENT
    • FOR ALZHEIMER'S

    COGNEX
  55. DONEPEZIL
    • ANTICHOLINESTERASE AGENT
    • FOR ALZHEIMER'S

    ARICEPT
  56. RIVASTIGMINE
    • COVALENT ANTICHOLINESTERASE AGENT
    • FOR ALZHEIMER'S

    EXELON (PATCH)
  57. GALANTAMINE
    • ANTICHOLINESTERASE AGENT
    • FOR ALZHEIMER'S

    RAZADYNE
  58. MEMANTINE
    • NMDA RECEPTOR ANTAGONIST
    • FOR ALZHEIMER'S

    NAMENDA
  59. CAPRYLIDENE
    MEDICAL FOOD FOR ALZHEIMER'S

    INCREASES KETONE BODIES IN THE BLOOD, WHICH INCREASES THE BRAIN'S BLOOD GLUCOSE UTILIZATION

    AXONA
  60. TETRABENAZINE
    FOR HUNTINGTON'S DISEASE (A HYPERKINETIC DISORDER IN EARLY STAGES)

    MOA: WANT TO REDUCE MOVEMENT

    1: INHIBIT VMAT2 - LOWER DA PRODUCTION

    2: BLOCK POST-SYNAPTIC STRIATAL D1 AND D2 RECEPTORS (SINCE DA ATTACHES TO EITHER OF THESE TO CREATE MOVEMENT IN NIGROSTRIATAL PATH)

    • SIDE EFFECT:
    • -INHIBITING VMAT LEADS TO LOWERED PRODUCTION OF DA, NE, EPI, 5HT, H

    • LOWERED NE, EPI MEANS HYPOTENSION
    • LOWERED H MEANS DROWSINESS
    • LOWERED 5HT MEANS DEPRESSION
    • LOWERED DA COULD MEAN EPS (PARKINSON'S LIKE SIDE EFFECTS)

    XENAZINE
  61. RILUZOLE
    • FOR AMYOTROPHIC LATERAL SCLEROSIS
    • (LOU GEHRIG'S DISEASE)

    MOA: LOWER GLUTAMATE TRANSMISSION

    • -BLOCKS VOLTAGE NA+ CHANNELS
    • -INHIBITS POST-SYNAPTIC GLUTAMATERGIC NMDA AND KAINATE Rs
    • -INCREASES ACTIVITY/EFFICIENCY OF GLUTAMATE REUPTAKE TRANSPORTERS

    DOES NOT AFFECT AMPA RECEPTORS

    METABOLIZED BY CYP 1A2 AND THEN GLUCURONIDATION

    CAN ELEVATE TRANSAMINASES, WHICH REQUIRES LIVER FUNCTION LAB TESTS

    RILOTEK
  62. BACLOFEN
    • SYMPTOMATIC TREATMENT OF SPASTICITY
    • (RESISTANCE TO MOVING A LIMB AT A JOINT, BUT FOLLOWED BY RELAXATION)

    MOA:

    -GABA-B (Gi COUPLED) AGONIST THAT WORKS PRIMARILY TO INHIBIT SPINAL CORD INTERNEURONS THAT ARE INVOLVED IN SYNAPTIC REFLEXES

    REMEMBER THAT BENZODIAEPINES WORK ON GABA-A RECEPTORS TO ESSENTIALLY GET THIS SAME RESULT, AMONGST OTHER THINGS
  63. GLATIRAMER
    FOR MULTIPLE SCLEROSIS

    COPAXONE
  64. INTERFERON BETA
    FOR MULTIPLE SCLEROSIS

    AVONEX, REBIF, BETASERON
  65. NATALIZUMAB
    FOR MULTIPLE SCLEROSIS

    TYSABRI
  66. MITOXANTRONE
    FOR MULTIPLE SCLEROSIS

    NOVANTRONE
  67. MODAFINIL
    CNS STIMULANT FOR NARCOLEPSY

    PROVIGIL
  68. AMPHETAMINE
    CNS STIMULANT FOR NARCOLEPSY/ADHD

    ADDERALL, DEXEDRINE, DEXTROSTAT
  69. METHAMPHETAMINE
    CNS STIMULANT USED TO TREAT NARCOLEPSY

    DESOXYN
  70. METHYLPHENIDATE
    CNS STIMULANT FOR NARCOLEPSY

    RITALIN,
  71. TRICYCLIC ANTIDEPRESSANTS ARE ALSO USED TO TREAT WHAT?
    NARCOLEPSY
  72. SSRIs ARE USED TO TREAT WHAT IN ADDITION TO DEPRESSION?
    NARCOLEPSY
  73. MONOAMINE OXIDASE INHIBITORS ARE USED TO TREAT WHAT IN ADDITION TO DEPRESSION?
    NARCOLEPSY
  74. GAMMA-HYDROXYBUTYRATE
    • CNS DEPRESSANT FOR NARCOLEPSY
    • (SLEEP AID)

    XYREM
  75. DISULFIRAM
    ETHANOL CONSUMPTION PREVENTATIVE

    ANTABUSE
  76. ACAMPROSATE
    ETHANOL CONSUMPTION PREVENTATIVE

    CAMPRAL
  77. NALTREXONE
    ETHANOL CONSUMPTION PREVENTATIVE

    REVIA, DEPADE
  78. BUPROPION

    (NOT GOING FOR ANTIDEPRESSANT THERAPY HERE)
    SMOKING CESSATION AGENT

    ZYBAN
  79. VARENICLINE
    SMOKING CESSATION AID

    CHANTIX
  80. NABILONE
    CANNABINOID RECEPTOR(CB1) AGONIST

    ANTIEMETIC

    CESAMET
  81. MARINOL
    CANNABINOID RECEPTOR(CB1) AGONIST

    ANTIEMETIC

    DRONABINOL
  82. MIXED THC + CANNABIDIOL
    CANNABINOID 1 & 2 RECEPTOR AGONIST

    ANALGESIC AND ANTIEMETIC

    SATIVEX
  83. ACOMPLIA
    CANNABINOID RECEPTOR ANTAGONIST

    RIMONABANT
  84. PHYSOSTIGMINE
    SUBSTRATE ANTICHOLINESTERASE

    REVERSIBLE, AND CARBAMYLATES ACH-ESTERASE

    100X AFFINITY OF ACH

    CLASSICAL PROTOTYPE OF ANTICHOLINESTERASES

    ESERINE, ANTILIRIUM
  85. PYRIDOSTIGMINE
    SUBSTRATE ANTICHOLINESTERASE

    CARBAMYLATES ACH-ESTERASE

    VIRTUALLY IRREVERSIBLE

    PROTONATED QUATERNARY AMMONIUM SALT DOES NOT ALLOW BBBX, SO NOT GOOD FOR PARKINSON'S, ONLY MYASTHENIAS GRAVIS

    REGENOL, MESTINON
  86. DONEPEZIL
    REVERSIBLE ANTICHOLINESTERASE

    LACKS CARBAMATE MOEITY

    PHTHALAMIDE DERIVITIVE, PHTHALAMIDE GROUP INTERACTS WITH HYDROPHOBIC BINDING SITE 2 ON ACH-ESTERASE

    DOES NOT HAVE ACTIVITY WITH THE ESTERATIC SITE ON ACH-ESTERASE

    OCH3 E-WITHDRAWING GROUP ADDS ACH-ESTERASE AFFINITY

    PIPERADINE BINDS ANIONIC SITE

    SATURATION OF AROMATIC RINGS WOULD LEAD TO LESS PI PI STACKING AND DECREASED ACTIVITY

    BENZENE RING BINDS HYDROPHOBIC BINDING SITE 1 ON ACH-ESTERASE

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