diabetes mellitus biochemistry.txt

Card Set Information

Author:
kepling
ID:
47028
Filename:
diabetes mellitus biochemistry.txt
Updated:
2010-11-03 11:18:29
Tags:
diabetes mellitus biochemistry
Folders:

Description:
diabetes mellitus biochemistry
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user kepling on FreezingBlue Flashcards. What would you like to do?


  1. What is the risk level and high level for diabetes in an FPG test?
    • Risk = 100-125
    • Diabetic level = >126
  2. What is the risk level and diabetic level in an OGTT?
    • Risk = 140-199
    • diabetic = >200
  3. What is the risk level and diabetic level in an HbA1c test?
    • Risk = ≥6% but <6.5%
    • Diabetic = ≥6.5%
  4. What are the 3 causes of hyperglycemia in type I?
    • 1) increased glycogenolysis
    • 2) increased liver and kidney gluconeogenesis
    • 3) decreased Glut-4 activity = less glucose uptake in muscle and adipose
  5. What causes hyperTAG in Type I?
    • increased lipolysis = more fatty acids converted into VLDL
    • less LPL b/c of less insulin = more VLDL in circulation
  6. What causes ketoacidosis in type I?
    • Increased FA from lipolysis
    • elevated B-oxidation = more Acetyl CoA
    • Acetyl CoA shunted to Ketogenesis
    • Dehydration + ketone bodies = ketoacidosis
  7. Why is IV insulin potentially dangerous?
    • Sometimes glucagon levels drop after administration
    • This can lead to too much insulin which leads to HYPOGLYCEMIA
  8. What are the two main causes of Type 2?
    • 1) insulin resistance
    • 2) slow B-cell death
  9. What is the main cause of Type 2?
    Obesity
  10. What are the two metabolic changes in Type 2?
    • 1) Hyperglycemia
    • 2) HyperTAG
  11. Why no ketoacidosis in Type 2?
    Still produce levels of insulin to induce anti-lipolysis so there is less B-oxidation and less Acetyl CoA to enter Ketogenesis
  12. What is Hyperosmolar syndrome of Type 2?
    The blood becomes so Hyperglycemic that it becomes viscous and leads to cerebral dehydration
  13. What are the three negative results of AGE molecules (glycation)?
    • 1) over-stimulated macrophage activity
    • 2) neuropathy/nephropathy b/c of easy oxidation
    • 3) infection b/c glycation = hard immune response
  14. What is the polyol pathway?
    • Increased glucose coming in contact with Aldose Reductase = Sorbitol
    • Sorbitol goes in to the eye and causes cataracts b/c of the extra profusion of water and the shifting of crystalline structures.

What would you like to do?

Home > Flashcards > Print Preview