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What is the dangerous UCB threshhold?
What are the two causes of Neonatal jaundice?
- 1) insufficient protein synthesis so lack of Albumin
- 2) huge RBC turnover from maternal RBC's in baby
What is kernicterus?
- When UCB enters the brain and causes encephalopathy.
- UCB levels rise above 20
How does blue light therapy help with jaundice?
- UCB has hydrogen bonding going on in various places
- Blue light breaks these bonds and makes UCB slightly amphipathic
- UCB is then excreted in the urine
Why does a person turn yellow when they have jaundice?
- UCB is hydrophobic
- Elastin is hydrophobic
- There is a hydrophobic/hydrophobic interaction
What is Type I C-Najjar Syndrome and what is the UCB level?
- no GT = UCB >20
- **use light daily but generally does not work for long because of thickening skin with age and lack of penetrance
What is Type II C-Najjar Syndrome and what is the UCB level?
Dysfunctional GT = UCB < 20 = less dangerous and less fatal than Type I
What is Gilbert Syndrome?
Defective promoter region for GT = less GT produced
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