Path Block 3 (GIb)

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Path Block 3 (GIb)
2010-11-04 13:57:35
Path Block GIb

Path Block 3 (GIb)
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  1. Where do most (95%) of hte Malignancues of the Stomach originate?
    • originate in the surface glandular epithelial
    • cells of the stomach (adenocarcinoma)

  2. What Classification do we used for Adenocarcinomas of the stomach?
    • The Lauren Classification
    • - Intesstinal
    • - Diffuse
  3. What do you see in the Intestinal Type of Cancer?
    • -non-Signet ring
    • - associated with H. Pylori
    • -Declining in incidence
    • -Occurs predominately in gastric antrum/pylorus; lesser > greater curvature
  4. What do you see in the Diffuse type of Stomach cancer?
    • •Increasing incidence
    • -Signet rings
    • No association with H.pylori
    • •Dismal 5-year survival, none to 1 or 2%
    • Occur throughout the stomach
    • •Linits Plastica!
  5. how is gastric carcinoma classified?

    What is Linitis Plastica?
    By depth of invasion

    • Linitis plastica is an extreme form of flat or depressed advanced gastric carcinoma.Linitis plastica
    • means thickening of the stomach
  6. This is Gastric Carcinoma

    See Heeped up Borders
    • Both are Gastric cancer.
    • 1st-- See signet ring cells= Diffuse type
    • 2nd-- see no signet rings just gland formation = Intestinal type
    • This is Gastric Cancer (Linitis Plastica type)
    • It is a diffuse type= Signet rings and NOT H.Pylori associated.
  7. Name some other Gastric Tumors (LLMMN)
    • •Lymphoma (MALT, B-cell)
    • •Mesenchymal (GIST)
    • •Neuroendocrine (Carcinoid)
    • •Lipoma
    • •Metastatic
  8. This is a Gastric MALT (B cell) Lymphoma

    It may be H. Pylori associated
  9. What does GIST stand for?
    Where does it arise from?
    What # occur in the stomach?
    Any markers?
    What do you see histologically?
    Are they aggressive?
    Treat with?
    • Gastrointestinal Stromal Tumor
    • Intestinal cells of Cajal
    • 2/3
    • cKIT
    • Spindle cell features
    • Most are non-Aggressive and low malignant potential
    • Gleevec
  10. see this tumor arising from Muscilaris Propria of the gastric wall, what is it?
    GIST tumor
  11. This is a slide of a c KIT positive tumor. What is it?
  12. What cells do you see in:
    • - Broners glands (make Bicarb)
    • - Heneth cells
    • - Peyers patches
  13. What are we looking at?
    Thiss is a pic of the Small intestine

    Note: Pilli and Goblet cells
  14. What are the Congenital Abnormalities in the small and large bowel?
    • Atresia and stenosis
    • Meckel Diverticulum
    • Hirschsprung Disease (Congenital Aganglionic Megacolon)
  15. What is Meckel Diverticulum?
    Where is it found?
    is it a true Diverticulum? What does this mean?
    are they Symptomatic?
    • •Failure of involution of the vitelline duct
    • Antimesenteric, found in distal ileum, within 1 m. of ileocecal valve
    • •True diverticulum, it contains all three layers of the bowel wall (mucosa, submucosa and muscularis propria)
    • - Most are asymptomatic
  16. Meckels Diverticulum
  17. What is Hirshsprung Disease (MEGA COLON)?
    What is always affected? What areas are usually affected?
    If the Mega colon perforates, it does this in the ______.
  18. •Portion of colon that lacks both Meissner submucosal and Auerbach myenteric plexuses (failed to migrate during divelopement)
    • •Rectum is always affected. The Rectum and the sigmoid are usually affected.
    • - Males are affected more
    • - can be genetic
    • -Cecum