Muscle and heart biochem.txt
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What is the function of ANT?
- Send one ATP out of the mitochondria and bring in one ADP into the mitochondria
- It is an antiport.
Where is CK generally bound?
M-band of sarcomere
Describe general cycle to produce Cr-P:
- ANT sends ATP to Inner mitochondrial space (IMS)
- Porin Bring Cr into IMS
- CK + ATP = Cr-P sent out of Porin and ADP sent back to IMM through ANT
What is the role of AMPK?
- Inhibit anabolic pathways that consume ATP
- Activate catabolic pathways that produce ATP
What is the pasteur effect?
increased rate of glucose metabolism during anaerobic conditions
Where is glycogen located in the sarcomere?
around the I-band
How many ATP from glucose and glycogen during anaerobic glycolysis?
- Glucose = 2 ATP
- Glycogen = 3 ATP
What are the four molecules that activate glycogen phosphorylase?
- ATP - offer one P (or use AMP or AMPK - glycogen phosphorylase)
- Calcium - phosphorylase kinase
What is McArdle disease?
- lack of glycogen phosphorylase = no G6P = lack of glucose from glycogen
- They need a high carb diet to use dietary glucose before exercising
What is the name of the Lactate shuttle in muscles?
How does AMPK accelerate B-oxidation?
It inhibits ACC2 (this produces isoforms of malonyl CoA which block B-oxidation)
What three molecules are accumulated upon AMP degradation?
- PiNH3 (PFK-1 activator through Higher pH)
- Adenosine (vasodilator)
What are the three substrates the heart uses for fuel?
- Fatty Acids
What happens to lactate and B-oxidation during intense exercise?
- Lactate goes up
- B-oxidation goes down b/c carnitine shuttle is stopped
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