Pharm Block 1 (kinetics)

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What is the formula for Loading dose?
With will F be if it is an IV fluid?
- Loading dose = (Vd)(Cp)
- (F)
- it is 100% absorbed into the blood stream so F=1
- Vd= volume of distribution (amount in the body)
- weight of man goes ontop
- Cp= concentration in plasma (amount in the plasma)
- PO= Loading dose
- F= bioavaiability
How many half lives for a drug to reach a steady state?

What is the formula for Dosing rate?
Formula for the Volume of distribution?
Formula for therapeutic index?

5 half lives

Dosing rate = Css (plasma level) X CL (clearance) The amount in X the amount out

Cd= dose / Cp

TI= margin of safety= LD/ED
What is Pka?
What form crosses the Basement membran?

it is the pH of a drug at which 1/2 is dissociated

non-ionized
Clearance formula?

What is formula for Infusion rate at steady state?

CL= rate of elimination/ Cp

Infustion rate= Cl X Cp
Maintainance dose?

Half life equation?

Maintanance dose =Cp X CL X time / F

T 1/2= .7/ Ke (elimination constant)

Ke= CL/ Vd
How much drug present at :

1 half life?
2 half lives?

The time to reach steady state is dependent only on?
- 50%
- 75%
Half life of drug
Steady state equation?

Css= Dose X F/ CL X Time
what is the difference between zero order and 1st order kinetics?
- Zero Order---
- –Constant Amount is eliminated per unit time
- –When dose increases, the plasma concentration increases disproportionally
- 1st order-
- –Constant % or fraction is eliminated per unit time
- –When there is a high concentration of drug in the plasma, elimination is high
Urine acidity effects on drug excretion

–acidic urine: favors excretion of basic drugs

–basic urine: favors excretion of acidic drugs
the
best predictor of intensity of drug activity ?

Cp

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Pharm Block 1 (kinetics)

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Pharm Block 1 (kinetics

Updated

11/6/2010, 3:03:47 PM

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