Pharm Block 1 (kinetics)
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What is the formula for Loading dose?
With will F be if it is an IV fluid?
Loading dose =
(Vd)(Cp)
(F)
- it is 100% absorbed into the blood stream so F=1
Vd= volume of distribution (amount in the body)
weight of man goes ontop
Cp= concentration in plasma (amount in the plasma)
PO= Loading dose
F= bioavaiability
How many half lives for a drug to reach a steady state?
What is the formula for Dosing rate?
Formula for the Volume of distribution?
Formula for therapeutic index?
5 half lives
Dosing rate = Css
(plasma level)
X CL
(clearance) The amount in X the amount out
Cd= dose / Cp
TI= margin of safety= LD/ED
What is Pka?
What form crosses the Basement membran?
it is the pH of a drug at which 1/2 is dissociated
non-ionized
Clearance formula?
What is formula for Infusion rate at steady state?
CL= rate of elimination/ Cp
Infustion rate= Cl X Cp
Maintainance dose?
Half life equation?
Maintanance dose =Cp X CL X time / F
T 1/2= .7/ Ke (elimination constant)
Ke= CL/ Vd
How much drug present at :
1 half life?
2 half lives?
The time to reach steady state is dependent only on?
50%
75%
Half life of drug
Steady state equation?
Css= Dose X F/ CL X Time
what is the difference between zero order and 1st order kinetics?
Zero Order---
–
Constant Amount is eliminated
per unit time
–When
dose increases
, the
plasma concentration increases disproportionally
1st order-
–
Constant % or fraction is eliminated
per unit time
–When there is a
high concentration of drug
in the plasma,
elimination is high
Urine acidity effects on drug excretion
–acidic urine: favors
excretion of basic drugs
–basic urine: favors excretion of
acidic drugs
the
best predictor of intensity of drug activity ?
Cp
Card Set Information
Author:
Anonymous
ID:
47660
Filename:
Pharm Block 1 (kinetics)
Updated:
2010-11-06 15:03:47
Tags:
Pharm Block kinetics
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Pharm Block 1 (kinetics
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