# Pharm Block 1 (kinetics)

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1. What is the formula for Loading dose?
With will F be if it is an IV fluid?
• (F)

- it is 100% absorbed into the blood stream so F=1

• Vd= volume of distribution (amount in the body)
• weight of man goes ontop
• Cp= concentration in plasma (amount in the plasma)
• F= bioavaiability
2. How many half lives for a drug to reach a steady state?

What is the formula for Dosing rate?
Formula for the Volume of distribution?
Formula for therapeutic index?
5 half lives

Dosing rate = Css (plasma level) X CL (clearance) The amount in X the amount out

Cd= dose / Cp

TI= margin of safety= LD/ED
3. What is Pka?
What form crosses the Basement membran?
it is the pH of a drug at which 1/2 is dissociated

non-ionized
4. Clearance formula?

What is formula for Infusion rate at steady state?
CL= rate of elimination/ Cp

Infustion rate= Cl X Cp
5. Maintainance dose?

Half life equation?
Maintanance dose =Cp X CL X time / F

T 1/2= .7/ Ke (elimination constant)

Ke= CL/ Vd
6. How much drug present at :

1 half life?
2 half lives?

The time to reach steady state is dependent only on?
• 50%
• 75%

Half life of drug
7. Steady state equation?
Css= Dose X F/ CL X Time
8. what is the difference between zero order and 1st order kinetics?
• Zero Order---
• Constant Amount is eliminated per unit time
• –When dose increases, the plasma concentration increases disproportionally
• 1st order-
• Constant % or fraction is eliminated per unit time
• –When there is a high concentration of drug in the plasma, elimination is high
9. Urine acidity effects on drug excretion
–acidic urine: favors excretion of basic drugs

–basic urine: favors excretion of acidic drugs
10. the
best predictor of intensity of drug activity ?
Cp
 Author: Anonymous ID: 47660 Card Set: Pharm Block 1 (kinetics) Updated: 2010-11-06 15:03:47 Tags: Pharm Block kinetics Folders: Description: Pharm Block 1 (kinetics Show Answers: