biochem lecture 26
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Pentose phosphate pathway alternate names
- Hexose monophosphate Shunt
- 6-phosphoglucuronate pathway
Products of the PPP are:
- NADPH (reductive biosynthesis)- fatty acids/steroids
- Ribose-5-phosphate for nucleic acids
- Glycolytic intermediates- glyceraldehyde-3-phosphate
Glycolysis, Pyruvate dehydrogenase, and the Tricarboxylic acid cycle are inhibited by ______ and stimulated by ___.
- inhibited by NADH, ATP
- stimulated by NAD+
Higher requirement for ribose-5-phosphate than NADPH G6P is converted to _________ and ___________.
fructose-6-phosphate and glyceraldehyde-3-phosphate by glycolytic path.
T/F PPP stage 1 is reversible
False, irreversible... decarboxylation of hexose to pentose yielding NADPH is irreversible.
Stage II in PPP is _____
Reversible, it leads to glycolytic intermediates.
Oxidative reactions (stage 1) are _____ whereas nonoxidative reactions (stage 2) are ______.
G6P important features (3)
- Catalyzes firststep in PPP
- uses NADP as cofactor (makes NADPH)
NADPH and NADH differences
NADPH uses high energy electrons for biosynthesis, NADH uses them to make energy (ATP)
major cellular reductant and sulfhydryl buffer, makes drugs more soluble.
Cytochrome P450 requires ______ as a cofactor to detoxify drugs, steroids, and alcohols.
G6P dehydrogenase mutations
- Slightly decrease life span
- alter function of G6PD
- alter Km and Vmax
- resist flaciparum malaria
Drugs that exacerbate G6PD
Antiobiotics, antimalarials, Antipyretics (acetanilide)
Glucoronic acis is conjugated to ______ and ________ compounds and produce a strongly acidic compound which is more water soluble.
exogenously and endogenously.
UDP-glucose dehydrogenase is used in what synthesis?
Glucoronic acid synthesis.
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