Lecture 57.txt

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Lecture 57.txt
2010-11-06 19:58:31
Biochem Skeletal Muscle Heart

Biochemistry of Skeletal Muscle and Heart
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  1. what are the three systems for ATP production in working muscle?
    • immediate sources- ATP, creatine phosphate, adenylate kinase
    • anaerobic metabolism- glycogen-lactate system
    • aerobic (oxidative) metabolism- glucose, fatty acids, amino acids
  2. what is the function of ANT?
    transporter of ADP and ATP, it is an antiport transpoter, 1 ATP in for 1 ADP out, resides on inner mitochondrial membrane
  3. what is the Pasteur Effect?
    increased rate of glucose metabolism seen under anaerobic conditions
  4. what is the major strategy of AMPK in in abrubt exercising muscle?
    • inhibit ATP consumption (anabolic pathways)
    • stimulate ATP production (catabolic pathways)
  5. what are two of the roles of calcium in the muscle when exercise has started (abrupt)?
    • initiates muscle contraction
    • binds to and activates calmodulin (the subunit of glycogen phosphorylase kinase-helps in activation of glycogen phosphorylase and breakdown of glycogen)
  6. how many ATP are produces form glycolysis via blood glucose?
    glycolysis via glycogen?
    • glucose: 2ATP
    • glycogen: 3ATP
  7. what is the rate limiting enzyme/step in glycolysis?
  8. what is the role of FAT (fatty acid transporter)?
    transports fatty acids across the sarcolemma of muscle cell
  9. what is the role of FABP (fatty acid binding protein)?
    carries fatty acids to mitochondria where they are activated to fatty acyl CoA