biochem lecture 28

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swynocker
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47771
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biochem lecture 28
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2010-11-06 20:18:02
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biochem lecture
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biochem 28 ex3
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  1. desaturation of fatty acids requires _______ and _____________.
    cytochrome b5, NADPH-cytochrome b5 reducase.
  2. Fatty acid is activated by attaching to
    acyl CoA
  3. Oxidation of fatty acid occurs here.
    Mitochondrial matrix.
  4. _______ is the transport molecule for fatty acids into the mitochondrial matrix.
    Carnitine.
  5. Oxidation of palmitate yields _ oxidations and _____ is the final product. Overall yield is ___ ATPs.
    • 7
    • Acetyl CoA
    • 106
  6. B-Oxidation oxidizes _______ fatty acids with ____ number.
    saturated, even
  7. odd chain fatty acids produce this.
    Propinolyl CoA
  8. Alpha-oxidation necessary for metabolism of _____ ____ fatty acid, uses fatty acid ________ which occurs in peroxisomes.
    • branched chain
    • a-hydroxylase
  9. synthesis of fatty acids
    • Subcellular location- cytosol
    • Carriers- citrate
    • acyl carrier- actyl carrier protein
    • activator- citrate
    • inhibitor- long chain fatty acid acyl CoA
    • product- palmitate
    • 4 step- cond, reduction, dehydrat, reduction
  10. degradation of fatty acid
    • subcellular location- mitochondria
    • carrier- carnitine
    • acyl carrier- CoA
    • activator- CoA
    • inhibitor- Malonyl CoA
    • product- acetly coa
    • 4 step- Dehydrogenation, hydration, dehydrog, thiolysis
  11. water soluble lipid based energy : _____ and ______
    Acetoacetic acid and B-hydroxybutyric acid
  12. Ketone body production occurs in the
    Mitochondrial matrix
  13. Ketone body formation can be considered an _______ pathway.
    Overfloew
  14. ketone body formation stimulated with acetyl-CoA accumulates due to ____ carbohydrate utilization, low level of _______, citrate synthase activity is ___.
    • Deficient
    • Oxaloacetate
    • low
  15. Energy for ketone bodies is derived from _______ being converted to acetoacetyl CoA in tissues other than the ____ such as the _____ and muslce.
    • B-hydroxybutyrate
    • Liver
    • Heart
  16. synthesis of lipids does the following
    • Increases release of insulin
    • protein phosphatase activity
    • inhibits hormone sensitive lipase
    • and activates acetyl CoA carboxylase (Rate limit enzyme)
  17. degradation of lipids does this
    • releases glucagon and epinephrine
    • protein kinase activity
    • inhibit acetyl coa carboxylase
    • activate hormone sensitive lipase

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