Biochem lecture 29

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swynocker
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47775
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Biochem lecture 29
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2010-11-06 20:36:03
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biochem lecture
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biochem 29 ex3
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  1. The major component of surfactant in the lungs is this
    DCPP (dipalmitoylphosphatidylcholine)
  2. DCPP is produced by ____ and prevents ______.
    type 2 epithelial cells, atelectasis
  3. Phosphatidyl choline synthesis rate limiting step is _________ and is regulated by ______ and ___________..
    • cytidylyl transferase reaction.
    • cAMP, fatty acyl-CoA
  4. phospholipase A1 and A2 can remove fatty acids from either carbon _ or Carbon _.
    1, 2
  5. acyl chains can be attached to the carbon that had the fatty acid removed by _______ or ______
    Tranacylase or acyltransferase
  6. Roles of cholesterol are:
    • Membrane structure
    • precursor to synthesis of steroid hormones and bile acids.
  7. Deposition of cholesterol in coronary arteties can lead to _____.
    Atherosclerosis
  8. plasma cholesterol is in an _______ form with fatty acid attached to C_.
    esterified, C3
  9. All carbon atoms of cholesterol are derived from _____.
    Acetate
  10. API target for cholesterol is in step _.
    Step 2,HMG-CoA converted to mevalonate
  11. All reduction reactions of cholesterol biosynthesis use _____ as a cofactor.
    NADPH
  12. __#__ moles of ____ are consumed during the conversion of HMG-CoA to mevalonate.
    2, NADPH
  13. HMG-CoA is most active in __________ state.
    dephosphorylated
  14. ______ stimulates the removal of phosphate and thereby, activates HMG-CoA reductase activity.
    Insulin
  15. Statins affect blood cholesterol levels by inhibiting __________ in the liver which results in increased expression of ___ receptor gene.
    Cholesterogenesis, LDL
  16. Cholesterol is excreted in the ___ as free cholesterol or ____ ____ following conversion to _____ ____ in liver.
    • Bile
    • Bile Salts
    • Bile Acids
  17. Most abundant bile acids in human are
    • chenodeoxycholic acid
    • cholic acid
  18. Bile acid synthesis significance
    Excretion is by feces is only mechanism for eliminating excess cholesterol.

    • bile acids solubilize cholesterol, none in gall bladder
    • facilitate digestion of TAGs acting as emulsifying agents.
    • Facilitate absorption of fat soluble vitamins

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