biochem lecture 30

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swynocker
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47780
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biochem lecture 30
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2010-11-06 20:56:16
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biochem lecture
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biochem 30 ex3
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  1. sphingolypids are abundant in _____ _____.
    Myelin sheaths
  2. Sphingomyelins are important phospholipids and structural lipids of _______ ___ _____..
    Nerve cell membranes
  3. Sphingolipids have _#_ nonpolar tails.
    2
  4. Niemann-pick is a lysosomal storage disease characterized by defects in ____ ____ _______.
    the enzyme acid sphingomyelins
  5. glycosphingolipid backbones are ____ and have a wide variety of carb. groups attached to carbon _.
    ceramides, 1
  6. Galactocerebrosides are found mainly in _____ cell membranes.
    Neuronal, glucocerebrosides are not found in neuronal cell membranes
  7. Fabry disease characterized by accumulation of _____ whereas Gauchers disease is accumulation of. ______.
    • Globosides
    • glucocerebrosides
  8. Fabry is assosciated with
    burnng pain in lower extremities
  9. gauchers is assosciated with
    liver amnd spleen enlargement, mental retardation in infants only.
  10. Gangliosides are differenct from globosides because they contain _____ of _____
    Varying amounts of NANA
  11. Prostaglandins constrict of dilate ___ _____ _____ and cause aggregation or declumping of platelets. They also regulate ____ ___, ______, and cell growth.
    • Smooth muscle cells
    • Inflammatory mediation, calcium
  12. Leukotrienes
    • Mediate allergys
    • Bronchoconstriction
  13. Thromboxane action are Vaso____, promotes platelet _____, and contracts smooth muscles.
    Constriction, aggregation
  14. Three classes of prostaglandins.
    • A - Contain beta-hydroxy-ketone ring
    • E- contain 1,3 diols
    • F- contain a,b-unsaturated ketones.

    Numbers denote # of unsatureaed bonds in the side chains.
  15. COX-1 is produced _____ whereas COX-2 is _____.
    Constitutively, induced
  16. Trigger for COX-2 is the following
    in monocytes and macrophages - PAF and IL-1
  17. NSAIDS inhibit both ____ and ____
    COX1 and COX2
  18. Eicosinoids are __ carbon atoms and include _____, ____, and ______
    • 20
    • PGs, TXs, and LT
  19. inhibtion of COX-1 is assosicated with
    NSAID induced ulcerations in the gut.

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