biochem lecture 30
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sphingolypids are abundant in _____ _____.
Sphingomyelins are important phospholipids and structural lipids of _______ ___ _____..
Nerve cell membranes
Sphingolipids have _#_ nonpolar tails.
Niemann-pick is a lysosomal storage disease characterized by defects in ____ ____ _______.
the enzyme acid sphingomyelins
glycosphingolipid backbones are ____ and have a wide variety of carb. groups attached to carbon _.
Galactocerebrosides are found mainly in _____ cell membranes.
Neuronal, glucocerebrosides are not found in neuronal cell membranes
Fabry disease characterized by accumulation of _____ whereas Gauchers disease is accumulation of. ______.
Fabry is assosciated with
burnng pain in lower extremities
gauchers is assosciated with
liver amnd spleen enlargement, mental retardation in infants only.
Gangliosides are differenct from globosides because they contain _____ of _____
Varying amounts of NANA
Prostaglandins constrict of dilate ___ _____ _____ and cause aggregation or declumping of platelets. They also regulate ____ ___, ______, and cell growth.
- Smooth muscle cells
- Inflammatory mediation, calcium
- Mediate allergys
Thromboxane action are Vaso____, promotes platelet _____, and contracts smooth muscles.
Three classes of prostaglandins.
- A - Contain beta-hydroxy-ketone ring
- E- contain 1,3 diols
- F- contain a,b-unsaturated ketones.
Numbers denote # of unsatureaed bonds in the side chains.
COX-1 is produced _____ whereas COX-2 is _____.
Trigger for COX-2 is the following
in monocytes and macrophages - PAF and IL-1
NSAIDS inhibit both ____ and ____
COX1 and COX2
Eicosinoids are __ carbon atoms and include _____, ____, and ______
inhibtion of COX-1 is assosicated with
NSAID induced ulcerations in the gut.
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