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Purines have _#_ ring(s).
Purine bases found in DNA are___ and ____
Adenine and Guanine
Pyrimidine have _#_ ring(s)
Pyrimidine bases are ___ and _____
Cytosine and Thymine (uracil in RNA)
Purine nucleosides end in -_____ and pyrmidines end in -_____.
Functions of nucleotides are _____ _____, physiological mediators, monomeric units of nucleic acids, components of ______ (CoA, FAD, NAD+, and NADP+), activated intermediates (____ and ____), and allosteric effectors.
- Energy metabolism
- SAM and CDP-choline
Purine synthesis starts with ___________ and ends with ___________. There are no regulatory steps and all contain _____.
- 5-phosphoriboxylamine, inosine-5-monophosphate
Synthesis of purines requires amino acids: _____, ____, and _____. Needs CO2 and one carbon units transfererred via THF (2).
- Glutamine (2)
IMP, AMP, and GMP all regulate _____ _____ _________.
Glutamine PRPP amidotransferase
PRPP is a biosynthetically "_____" molecuke
ADP/GDP levels- ________ feedback on Ribose phosphate pyrophosphokinase
Amidophosphoribosyl transferase is activated by ____ levels.
Purine salvage is essential because
The body only has so much purine so it must recycle
CPSI and CPSII differences
CPSI- mitochondria, urea cycle, ammonia (nitrogen), and activator is N-acetyl-glutamate
CPSII- cytosol, pyrimidine synthesis, gamma-amide group of glutamine, activator is ATP, inhibitor is UTP
Nitrogen from glutamine amide, aspartate, and Carbon from carbonate.
Cellular balance is between ___ and ___ based on relative concentrations.
UTP and TMP