Biochem lecture 34

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swynocker
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47811
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Biochem lecture 34
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2010-11-06 23:13:43
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Biochem lecture
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Biochem 34 ex3
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  1. Purines have _#_ ring(s).
    2
  2. Purine bases found in DNA are___ and ____
    Adenine and Guanine
  3. Pyrimidine have _#_ ring(s)
    1
  4. Pyrimidine bases are ___ and _____
    Cytosine and Thymine (uracil in RNA)
  5. Purine nucleosides end in -_____ and pyrmidines end in -_____.
    • -sine
    • -dine
  6. Functions of nucleotides are _____ _____, physiological mediators, monomeric units of nucleic acids, components of ______ (CoA, FAD, NAD+, and NADP+), activated intermediates (____ and ____), and allosteric effectors.
    • Energy metabolism
    • coenzymes
    • SAM and CDP-choline
  7. Purine synthesis starts with ___________ and ends with ___________. There are no regulatory steps and all contain _____.
    • 5-phosphoriboxylamine, inosine-5-monophosphate
    • ribose
  8. Synthesis of purines requires amino acids: _____, ____, and _____. Needs CO2 and one carbon units transfererred via THF (2).
    • Glycine
    • Glutamine (2)
    • aspartate
  9. IMP, AMP, and GMP all regulate _____ _____ _________.
    Glutamine PRPP amidotransferase
  10. PRPP is a biosynthetically "_____" molecuke
    control
  11. ADP/GDP levels- ________ feedback on Ribose phosphate pyrophosphokinase
    Negative
  12. Amidophosphoribosyl transferase is activated by ____ levels.
    PRPP
  13. Purine salvage is essential because
    The body only has so much purine so it must recycle
  14. CPSI and CPSII differences
    CPSI- mitochondria, urea cycle, ammonia (nitrogen), and activator is N-acetyl-glutamate

    CPSII- cytosol, pyrimidine synthesis, gamma-amide group of glutamine, activator is ATP, inhibitor is UTP
  15. Pyrimidine characteristics
    Nitrogen from glutamine amide, aspartate, and Carbon from carbonate.
  16. Cellular balance is between ___ and ___ based on relative concentrations.
    UTP and TMP

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