Biochem lecture 35

Deoxyribonucleotides are formed by the reduction of ______ ______

All deoxyribonucleotides are synthesized from ribonucleotides by the enzyme _______ ___________.

The enzyme ribonucleotide is highly _____.

Deoxythymidylate is formed by the ___________ of deoxyuridine-5-monophosphate

UMP is the precursor for all the _______ nucleotides

Pyrimidine nucleotides are degraded to __________.

When nucleotides are converted to nucleosides the end products are ______ and ________.

Nucleotide function in coenzyme synthesis ___ ____ and
____

Name for NAD

FAD

FAD precursor is _____

CoA precursor is ______

PRPP is the key molecule in ___ ___ synthesis of purine and pyrmidine nucleotides, ______ of purine pyrimidine bases, and synthesis of ____.

dUMP can be converted to dTMP using ________ _________.

Thymidylate synthase is an enzyme targeted by anti cancer drugs such as _____.

Regerneration of THF from DHF requires _________ ________, an enzyme targeted by the drug __________.

Fluorouracil is a ______ inhibitor meaning it is a noncompetitive antagonist.

examples of purine analogs are

Pyrimidine analogs

Acyclovir is a _____ analog and AZT is a ________ analog are used in the treatment of HSV and HIV.