Biochem lecture 35
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Deoxyribonucleotides are formed by the reduction of ______ ______
All deoxyribonucleotides are synthesized from ribonucleotides by the enzyme _______ ___________.
The enzyme ribonucleotide is highly _____.
Deoxythymidylate is formed by the ___________ of deoxyuridine-5-monophosphate
UMP is the precursor for all the _______ nucleotides
Pyrimidine nucleotides are degraded to __________.
When nucleotides are converted to nucleosides the end products are ______ and ________.
Uracil and thymine (Uracil turns into B-alanine) (Thymine turns into B-aminoisobutyrate)
Nucleotide function in coenzyme synthesis ___ ____ and
Name for NAD
Nicotinamide adenine dinucleotide
Flavin Adenine dinucleotide
FAD precursor is _____
CoA precursor is ______
PRPP is the key molecule in ___ ___ synthesis of purine and pyrmidine nucleotides, ______ of purine pyrimidine bases, and synthesis of ____.
- de novo synthesis
dUMP can be converted to dTMP using ________ _________.
Thymidylate synthase is an enzyme targeted by anti cancer drugs such as _____.
Regerneration of THF from DHF requires _________ ________, an enzyme targeted by the drug __________.
- dihydrofolate reductase
Fluorouracil is a ______ inhibitor meaning it is a noncompetitive antagonist.
examples of purine analogs are
6-mercaptopurine and acycloguanosine
- cytosine arabinoside
Acyclovir is a _____ analog and AZT is a ________ analog are used in the treatment of HSV and HIV.
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