Biochem lecture 35

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swynocker
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47816
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Biochem lecture 35
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2010-11-06 23:30:22
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Biochem lecture
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Biochem 35 ex3
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  1. Deoxyribonucleotides are formed by the reduction of ______ ______
    Ribonucleoside diphosphates
  2. All deoxyribonucleotides are synthesized from ribonucleotides by the enzyme _______ ___________.
    Ribonucleotide reductase
  3. The enzyme ribonucleotide is highly _____.
    Regulated
  4. Deoxythymidylate is formed by the ___________ of deoxyuridine-5-monophosphate
    methylation
  5. UMP is the precursor for all the _______ nucleotides
    pyrimidine
  6. Pyrimidine nucleotides are degraded to __________.
    B-amino acids
  7. When nucleotides are converted to nucleosides the end products are ______ and ________.
    Uracil and thymine (Uracil turns into B-alanine) (Thymine turns into B-aminoisobutyrate)
  8. Nucleotide function in coenzyme synthesis ___ ____ and
    ____
    • NAD
    • FAD
    • Coenzyme A
  9. Name for NAD
    Nicotinamide adenine dinucleotide
  10. FAD
    Flavin Adenine dinucleotide
  11. FAD precursor is _____
    Riboflavin
  12. CoA precursor is ______
    Pantothenate
  13. PRPP is the key molecule in ___ ___ synthesis of purine and pyrmidine nucleotides, ______ of purine pyrimidine bases, and synthesis of ____.
    • de novo synthesis
    • Salvage
    • NAD+
  14. dUMP can be converted to dTMP using ________ _________.
    Thymidylate synthase
  15. Thymidylate synthase is an enzyme targeted by anti cancer drugs such as _____.
    5-fluroucracil
  16. Regerneration of THF from DHF requires _________ ________, an enzyme targeted by the drug __________.
    • dihydrofolate reductase
    • methotrexate
  17. Fluorouracil is a ______ inhibitor meaning it is a noncompetitive antagonist.
    Suicide
  18. examples of purine analogs are
    6-mercaptopurine and acycloguanosine
  19. Pyrimidine analogs
    • 5-fluorouracil
    • cytosine arabinoside
    • AZT
  20. Acyclovir is a _____ analog and AZT is a ________ analog are used in the treatment of HSV and HIV.
    Purine, pyrimidine

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