Acute Renal Failure
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Acute Renal Failure
Acute Renal Failure
Therapeutics Week 9 - Acute Renal Failure
Define acute renal failure
An abrupt decrease in GFR occurring over hours to days (sometimes weeks). Assoc with acumulation of waste products including urea and creatinine.
What is normal urine output?
Greater than or equal to 1200 ml/day
What is anuric?
Urine output < 50 ml/day
What is oliguric?
UO < 500 ml/d
What is nonoliguric?
UO > 500 ml/day
Define the RIFLE characteristics
: Risk of dysfunction. SCr up 50% or GFR down 25% and UO < 0.5 ml/kg/h x 6h
: Injury. SCr up 100% or GFR down 50% and UO < 0.5 ml/kg/hr x 12 h
: Failure. SCr up 200% or > 4 mg/dl or GFR down 75% and UO < 0.3 ml/kg/h x 24 h or anuria x 12 h
: Loss. ARF > 4 weeks
: End Stage Renal Disease. ESRD > 3 months
Define Prerenal renal failure
ARF caused by decreased renal perfusion in the absence of damage to parenchymal tissue. Often assoc with volume depletion or poor cardiac function. (Blood loss, dehydration)
Define Intrinsic renal failure
Structural damage to the kidney - usually the tubule - d/t ischemia or toxicity. (contrast induced nephropathy)
Define Postrenal failure
D/T obstruction of urine flow downstream from the kidney. Usually not drug-induced. (Prostate, foley)
What cause of ARF is the most common in the hospital setting?
Prerenal ischemia d/t decreased renal perfusion secondary to sepsis, reduced CO, or surgery
4 causes of decline in intravascular blood volume, leading to prerenal azotemia
1. acute blood loss
4. diuretic therapy
What is prerenal azotemia?
Elevated blood levels of urea in the serum
What typically causes renal vasculature damage? (it is rare)
Atherothrombi dislodged during a procedure or thromboemboli from pts with severe HF or AFib
Glomerular damage can occur d/t emboli and . . .
Severe inflammatory processes as seen in SLE and poststreptococcal glomerulonephritis
What is the cause of 85% of all ARF?
Tubule Damage (acute tubular necrosis)
Of the 85% of ARF attributed to ATN, 50% is due to _________ and 35% is due to _____________
50% to renal ischemia
35% to exposure to direct tubule toxins
Tubular injury leads to:
1. Inability to concentrate urine
2. Defective distal sodium reabsorption
3. Decreased GFR
What is the time frame for the maintenance phase and the recovery phase of ATN?
2-3 weeks per phase
Interstitial damage is most commonly caused by:
bacterial or viral infections
List the most common causes of Postrenal ARF
1. Bladder outlet obstruction due to a prostatic process (enlarged prostate)
2. Improperly placed urinary catheter
3. Neurogenic bladder
4. Anticholinergic meds
Give the lab values that indicate Prerenal ARF for urine sodium, FENa, Urine/serum osmolality, Urine/Scr, BUN/Scr
: < 20
: < 1
: > 1.5
: > 40:1
Give the lab values that indicate Intrinsic ARF for urine sodium, FENa, Urine/serum osmolality, Urine/Scr, BUN/Scr
: > 40
: > 2
: < 1.3
: < 20:1
: approx 15
Give the lab values that indicate Postrenal ARF for urine sodium, FENa, Urine/serum osmolality, Urine/Scr, BUN/Scr
: > 40
: < 1.5
: < 20:1
: approx 15
What meds can disrupt the usefulness of FENa in diagnosing ARF?
Diuretics (mainly loops)
At what potassium concentrations is immediate treatment of hyperkalemia required?
> 7 OR 6.1 - 6.9 if there are EKG changes
Does calcium affect potassium?
What is the initial treatment of hyperkalemia and how does it work?
Calcium to protect/stabilize the heart. It antagonizes the action of K+ on cardiac membranes.
What is the secondary treatment for hyperkalemia?
Decrease extracellular K+ by promoting its movement into cells using glucose, insulin, B2 receptor agonists, sodium bicarb), or enhance its removal using dialysis or exchange resins.
MOA of furosemide
Inhibit renal Na+ reabsorption (incr K+ out in urine)
MOA of sodium polystyrene sulfonate (kayexelate)
Resin exchanges Na+ for K+ (incr K+ elimination)
MOA of calcium
Raises cardiac threshold potential (reverses electrocardiographic effects)
MOA of sodium bicarb
Raises serum pH. (intracellular K+ redistribution - back into cell)
Insulin and Glucose MOA
Insulin stimulates intracellular K+ uptake
Beta Agonists MOA
Stimulate intracellular K+ uptake
Removal from serum (incr K+ elimination)
Why do we stop metformin in patients with ARF?
It puts pt at higher risk for lactic acidosis
Which medications can cause ARF?
Bactrim (can incr SCr without causing ARF, or can cause ARF)
MOA of renal failure secondary to aminoglycosides
(e.g. gentamicin, tobramycin, amikacin, netilmicin)
Progressive rise in SCr and decrease in CrCl after 6-10 days of therapy. Result of proximal tubular epithelial cell damage leading to obstruction of the tubular lumen.
MOA of renal failure secondary to contrast dye
Direct tubular toxicity and/or renal ischemia
MOA of renal failure secondary to Vancomycin
Oxidative stress and renal tubular toxicity
Discuss the meta-analysis of the relative efficacy and toxicity of SDD vs. MDD of Aminoglycosides
: Not pregnant, Not children, No renal dysfunction, Normal weight, undergoing AG for any G- infection
: (resolution of s/s) Trend favoring SDD
: No difference - indeterminant
: No significant difference, but a trend for SDD to be used - less toxic
: Easy to clear infx were looked at - more serious might have been better.
Discuss the meta-analysis about effectiveness of drugs for preventing contrast-induced nephropathy
Is N-acetylcystine effective? Yes, but only with NS, not alone
Theophylline? Not statistically. Yes, but very narrow therapeutic window
Ascorbic acid? Yes
Furosemide? No, increased the risk
Fenoldopam? No, increased the risk
Mannitol? No, increased the risk
Dopamine? Not really any benefit seen
Issues with the meta-analysis - Some of the studies had low quality scores. Not all had the same risk factors. Volume and type of contrast makes a difference and this was not always controlled for.
Discuss the journal article about the relationship between initial vancomycin concentration-time profile and nephrotoxicity among hospitalized patients
Definition of SCr change (nephrotoxicity)
: 0.05 increase of 50% on at least 2 consecutive days
Important baseline characteristics
: Pt weight > 101 kg. Trough value. Residents in ICU at time of onset.
Rate of renal toxicity
: if trough value was > 20, up to 33%
: Need 7 days to see renal tox to vanco. If creatinine goes up the next day, it's probably d/t something else.
MOA of renal failure d/t interaction of ACE-I, ARBs and NSAIDS
NSAIDs constrict the afferent arterioles into kidney.
ACEs, ARBs dilate the efferent arterioles out of the kidney.
No pressure inside kidney. Kidney needs pressure to work, so ARF.