Physio- endocrinology

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Author:
Anonymous
ID:
47922
Filename:
Physio- endocrinology
Updated:
2010-11-07 14:11:55
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physio
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physio
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  1. Type I DM is +/- of:
    insulin
  2. Type II is +/- of
    Relatively - insulin, Insulin Resistance
  3. Clinical Signs of DM (7)
    • PU/PD
    • polyphagia
    • Anorexia/vomiting (later)
    • Weight loss
    • Swelling
    • Neuropathies/Microangiopathies
    • UTI
  4. <Metabolic/Physiological changes that result from DM (5):
    • Hyperglycemia (decreased cell uptake and increased gluconeogenesis)
    • Proteolysis
    • Lipolysis
    • Reduced glycogenesis
    • Reduced protein synthesis
  5. Clinical Signs of hyperthyroidism (8):
    • Weight loss/muscle atrophy
    • Appetite: Normal-Increased
    • Nervousness
    • Heat Intolerance
    • Tachycardia/hypertension
    • Diarrhea
    • PU/PD
    • Skin Changes
  6. Clinical signs of Hypothyroidism (9):
    • Lethargy
    • Weight Gain
    • Exercise Intolerance
    • Heat Seeking
    • Myxedema
    • Dry skin
    • Alopcia
    • Hyperpigmentation
    • Dec Reproduction
  7. Goiter results from a ____ deficiency
    I
  8. Goiter Clinical signs are similiar to:
    Hypothyroidism
  9. Growth hormone stimulates which metabolic pathways?
    • Lipolysis
    • Insulin Resistance
    • Protein Synthesis
  10. Growth Hormone deficiency in juvenile => (2)
    • Dwarfism
    • Alopecia
  11. Growth Hormone deficiency in Adult => (2)
    • Aging
    • Panhypopituitarism (FSH/LH, ACTH, Thyroid)
  12. Growth Hormone Excess in juveniles =>
    Gigantism
  13. Growth Hormone Excess in adults =>
    • Acrmegaly
    • Increased bone/cart in face/joints
    • Cardiac Hypertrophy
    • Seconday DM
  14. _____ -> Excess GH in Dogs
    _____ -> Excess GH in Cats
    • ++ progesterone -> Dogs
    • Pituitary tumor -> Cats
  15. Decreased Glucocorticoids
    • Addison's
    • (Also Decreased Mineralcorticoids)
  16. Increased Glucocorticoids =>
    Cushings
  17. Stress Hormones =
    Glucocorticoids
  18. Primary metabolic functions of glucocorticoids
    • Increase Gluconeogenesis
    • Increase Glycogenesis
    • Increa
  19. Primary metabolic functions of glucocorticoids (3)
    • Increase Gluconeogenesis
    • Increase Glycogenesis
    • Increase Proteolysis
  20. Organs/Tissues affected by Glucocorticoids:
    • Liver
    • GI
    • BG
    • CNS/Pituitary
    • Muscle
    • CT
    • Fat
    • Bone
    • Blood
    • Inflammatory Mediators
  21. POMC => (4)
    • a-MSH
    • B- Endorphin
    • CLIP
    • ACTH
  22. Primary Causes of Cushings:
    • Adenoma of Ant. Pituitary (most common)
    • Iatrogenic
    • Pars Intermedia Tumore (Horses
    • Adenoma of Adrenal Gland (rare)
  23. Clinical Signs of Cushing's (13):
    • Muscle Atrophy
    • Weakness
    • Think Skin
    • BILATERAL hair loss
    • Slow shedding (horses)
    • Lightened coat color
    • Potbelly
    • PU/PD
    • Suppressed Immune
    • Polyphagia
    • Panhypopituitarism
    • Behavoir Changes (horse)
    • Hyperpigmentation
  24. Mitotane Tx is used to:
    supress adrenocortex
  25. Renal Hypertension is caused by
    Hyperaldosteronism
  26. Mineralcorticoid Deficiency =>
    Na and Water Retention

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