Glomerulonephritis

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Author:
cathy4xo
ID:
48399
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Glomerulonephritis
Updated:
2010-11-09 05:53:50
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Glomerulonephritis
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Glomerulonephritis
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  1. What are 4 types of glomerulonephritis most commonly associated with nephritic syndrome? (descending order)
    • 1. Post-streptococcal glomerulonephritis
    • 2. Crescentic glomerulonephritis
    • 3. IgA nephropathy
    • 4. Membranoproliferative glomerulonephritis
  2. What are 3 things we need for know before performing a renal biopsy?
    • 1. Bleeding time (platelet count, PT) - patients with uraemia may have prolonged bleeding
    • 2. Blood pressure
    • 3. Anatomy of kidneys (U/S required)
  3. Describe the pathogenesis of post-streptococcal glomerulonephritis.
    • Antigens deposit in glomerular capillaries, commonly reside between glomerular membrane and podocytes
    • Antibodies bind to antigens and form immune complexes
    • Complement is activated (C3a & C5a) and they are chemotactic for leukocytes
    • C3a & C5a cause histamine release from mast cells, leading to increased vascular permeability
    • C5b-C9 complex directly damages glomerular membrane
    • Intercellular adhesion molecules causes adhesion of cells to endothelium
    • Podocytes are damaged and retract
    • Blood and protein enters Bowman's space
  4. Name 5 types of glomerulonephritis associated with nephrotic syndrome.
    • 1. Membranous glomerulonephritis
    • 2. Focal segmental glomerulonephritis
    • 3. Minimal change disease
    • 4. Membranoproliferative glomerulonephritis
    • 5. Diabetic glomerosclerosis
  5. Name 3 clinical problems associated with proteinuria.
    • Hypercoagulability -- e.g. renal thrombus
    • Increased infection risk
    • CVD
  6. Name 4 common causes of membranous glomerulonephritis.
    • SLE
    • Drugs e.g. gold, NSAIDS, captopril
    • Infections e.g. hep B, malaria
    • Cancers e.g. carcinoma, melanoma, leukaemia
  7. Name 2 types of glomerulonephritis associated with asymptomatic urinary abnormalities.
    • IgA nephropathy - Berger's disease
    • Thin basement membrane disease

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