Describe the pathogenesis of oedema, hypercholesterolemia, hypoalbuminemia and infections in nephrotic syndrome.
- Oedema: low oncotic pressure due to hypoalbuminaemia and retention of salt/water by kidneys
- Hypercholesterolemia: liver overproducing lipoproteins due to fall in oncotic pressure
- Hypoalbuminemia: urinary protein loss, increased catabolism of filtered albumin (proximal tubule), redistribution of albumin within body
- Infections: urinary loss of immunoglobulins and defect in complement cascade