CNS 2 TEST 1.2

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cmg7737
ID:
49624
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CNS 2 TEST 1.2
Updated:
2010-11-14 23:11:43
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CNS TEST
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CNS 2 TEST 1.2
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  1. FLUOXETINE
    SSRI (PROZAC)

    LONG 1/2 LIFE (NORFLUOXETINE METABOLITE SO GREAT FOR NONCOMPLIANCE)

    • 20-60MG/DAY
    • 90MG/DAY MAX

    INHIBITS 2D6, 3A3/3A4

    ACTIVATING - SO TAKE IN MORNING

    HA, STOMACH UPSET, WEIGHT LOSS, SEXUAL DYSFUNCTION
  2. SERTRALINE
    SSRI (ZOLOFT)

    50-200MG/DAY

    INHIBITS 2Cs, 2D6

    ACTIVATING

    INTERMEDIATE 1/2 LIFE, SO COULD LEAVE WITHDRAWAL SYMPTOMS (FLU LIKE)
  3. PAROXETINE
    SSRI (PAXIL)

    20-60MG/DAY

    *LEAST ACTIVATING + ANTICHOLINERGIC SO NOT FOR WEARY/MOTOR RETARDED

    POTENT 2D6 INHIBITOR

    INTERMEDIATE 1/2 LIFE SO WITHDRAWAL SYMPTOMS

    INCREASE IN CONGENITAL MALFORMATIONS, PREGNANT WOMEN STAY AWAY (ACCORDING TO ONE STUDY AT LEAST)

    POSSIBLE TERATOGEN
  4. CITALOPRAM
    SSRI (CELEXA) R & S ISOMERS

    20-60MG/DAY

    • 3A4 INHIBITOR
    • 2D6 INHIBITOR (WEAK)

    • POSSIBLY LESS SEXUAL DYSFUNCTION
    • WITHDRAWAL SYMPTOMS
    • HIGHLY SERT SELECTIVE
    • ACTIVATING
  5. FLUVOXAMINE
    SSRI (FOR OCD, NOT MDD) (LUVOX)

    50-300MG/DAY

    • INDICATED FOR OCD
    • LONG 1/2 LIFE

    INHIBITS 1A2, 3A4, 2C19

    • WITHDRAWAL SYNDROME
    • N&V STOMACH ISSUES, AGITATION, INSOMNIA, SEXUAL DYSFUNCTION
  6. VENLAFAXINE/DESVENLAFAXINE
    SNRI (EFFEXOR/PRISTIQ)

    • 37.5-225MG/DAY
    • SHORT 1/2 LIFE SO BID
    • LOWEST PROTEIN BINDING

    MINOR 2D6 INHIBITOR, FEW DRUG INTERACTIONS

    DOSE RELATED HTN DUE TO NE COMPONENT, SO MORE DANGEROUS IN OVERDOSE CASES
  7. DULOXETINE
    • SNRI (CYMBALTA)
    • ALSO FOR DIABETIC NEUROPATHY/PAIN

    • 30-90+MG/DAY
    • TMAX 6HRS, 1/2 LIFE 15HRS

    • METABOLIZED BY 1A2 AND 2D6, SO INHIBITORS OF THESE WILL INCREASE CYMBALTA CONCENTRATIONS
    • INHIBITS 2D6 MODERATELY

    NAUSEA, DRY MOUTH, CONSTIPATION, INSOMNIA, DIZZINESS
  8. BUPROPION
    DAT/NET BLOCKER (WELLBUTRIN/ZYBAN)

    • CONTROLLED RELEASE UP TO 200MG BID
    • EXTENDED RELEASE QD <450MG/DAY

    *LOWERS SEIZURE THRESHOLD

    *LESS SEXUAL DYSFUNCTION THAN SSRIs, AND NO WITHDRAWAL

    AGITATION, NAUSEA, INSOMNIA, PSYCHOSIS, DOSE RELATED SEIZURES

    DRUG INTERACTIONS WITH ANTIEPILEPTICS, AND RITONAVER WOULD INCREASE LEVELS OF BUPROPION
  9. TRAZADONE/NEFAZADONE
    • (DESYREL)
    • MORE FOR SLEEP AT 50MG THAN ANTIDEPRESSANT

    3A4 INHIBITOR, SO BAD WITH RITONIVIR AND BENZOS

    COMBINE WITH SSRIs AND MAOIs FOR SEROTONIN SYNDROME

    PRIAPISM
  10. MIRTAZEPINE
    REMERON

    ANTIHISTAMINIC AND SEDATIVE AT LOW DOSES, NOT SO MUCH AT HIGHER DOSES

    • WEIGHT GAIN
    • LIVER ENZYME ELAVATION (MONITOR LFTs)

    METABOLIZED BY 3A4, 2D6, 1A2, 2C9, SO VERY FEW DRUG INTERACTIONS

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