Capsules DF 2

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Author:
swynocker
ID:
49645
Filename:
Capsules DF 2
Updated:
2010-11-15 00:07:30
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Capsules DF2
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Capsules DF 2
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  1. Capsule definition
    Gelatin capsule filled with medicine to produce a "unit dose"
  2. Soft gelatin capsules are usually filled with
    liquid
  3. Hard gelatin caps are usually filled with
    powders, but could be NON AQUEOUS LIQUIDS!!!
  4. Advantages of hard gelatin
    • Great versatility
    • Protect/mask ingredients within
    • patient acceptance
    • Enteric coating
  5. Disadvantages of hard gel cap
    • Moisture can alter capsule or drug
    • Succeptible to tampering
    • possible esophageal adhesion
  6. Steps for making capsules
    • 1. fll with empty capsules
    • 2. orient capsules
    • 3. powder filling
    • 4. close cap
    • 5. done
  7. Gelatin is made mainly from collagen which comes from these 3 animals
    Cows, pigs, and fish
  8. 3 important thigns about gelatins
    • non toxic
    • dissolve in bodily fluids and body temp
    • forms a good film
  9. Water content in gelatin is about
    12-16%
  10. Colorants/opacifiers are used to help ____ the capsule and help ____ the drug.
    • Identify
    • Protect
  11. Examples of colorants and opacifiers
    • Colorant: iron oxide
    • Opacifier: titanium dioxide
  12. Fill weight of capsules is based on
    Density
  13. Capsule fill weight= tapped bulk _____ X Capsule _____
    • Density
    • Volume
  14. T/F the larger the capsule the higher the number
    False, lower
  15. Diluents act as ____ to make up required bulk
    • Filler
    • (Starch, lactose)
  16. Glidants reduce interparticulate friction by filling spaces and improve particle ___.
    • Flow
    • (Talc, silicone dioxide)
  17. Lubricants reduce particle to metal _____.
    • Adhesion
    • (magnesium stearate, dimethicone)
  18. Disintegrants ... obvious but they promote____
    • Disintegration
    • (pregelatiinized starch, starch glycolate)
  19. T/F Hydrophobic diluents can significant increase drug dispersion and dissolution rate of poorly soluble/ hydrophobic drugs.
    False, hydrophillic diluents
  20. Factors impacting dissolution from capsules
    • Diluents
    • Packing density
    • Particle size
    • Lubricant
  21. Examples of locking/sealing are
    • Dimples
    • Grooves
    • spot welding
    • fusion
    • Band
  22. Advantages of soft gel
    • Good alternative for liquid drugs
    • high precision per fill
    • improve bioavailabilty
    • improve elegance
    • relatively tamperproof
  23. disadvantages of soft gel
    • drug migration to shell
    • limited to liquid
    • limited number of firms? NOT NO MORE!!!
  24. Capsules appear hard due to
    turgor pressure
  25. Composition of soft gel
    • Gelatin
    • Plasticizer (obtain softness and flexibility)
    • colorants/opacifiers
  26. Contents of soft gel
    • Water imicible liquids (veg. oil)
    • Water miscible liquids (low MW PEGs, glycerin, propylene glycol)

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