Tablets DF 2
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Tablets can vary in many ways including size, shape, color, Disintegration/______, and usage.
Advantages of oral tablets are
- easy to package/transport
- tamper resistent
- patient acceptance
Disadvantages of oral tablets
- limited dosage flexibility
- complex formulation requiremtns
- esophogeal adheasion
T/F some machines can produce 250 tablets for second
T/F powder is fed into Dials and compressed at high pressure using kickers.
False, Fed into dies and compressed with punches.
Paradox for compressed tablets, to make it strong enough for processing and handling but capable of _______
Breaking down upon administration
Essential properties of powders are _____ and _______.
- Fluidity- powder must flow into dies well
- Compresability- must form stable intact mass when pressure is applied
These are used to improve fluidity
Glidants, lubricants and granulation
these are used to improve compressability
special excipients and granulation
Purposes of granulation are to prevent _______, improve powder fluidity, and improve powder _____.
Excipients for Tablet formulation are _______ (diluents), _______, ______, _______, and _____.
- Filler- starch
- adhesive- Providone
- glidant- colloidal silica, talc
- Lubricant- magnesium stearate
- disintegrant- starch, cellulose derivatives
Tablet formulation approaches
Wet/dry granulation and direct compression.
Direct compression is used for drugs with both ____ and _____ properties.
Cohesive and flow, not many drugs have both properties.
Tablet coating reasoning
- Protect ingredients
- mask taste
- facilitate swallowing
- mask differences
- tablet ID
- manufacture distribution
- Enteric and controlled release
Types of coating are
- Sugar coating without indentations
- Film coating wtih indentations
Pioneers of gel coating are
The special pH polymer used in enteric coating is
cellulose acetate pthalate
Enteric polymers work by _____ groups on polymer backbone which allows solubility to increase at a pH of ____.
Tests to assure tablet quality are
Appearance- mottling or cracking
Thickness- determine by fill volume, die diameter, comp pressure.
- Hardness- crushing strength required
- Friability- tendency to crumble
- USP tests- drug content and drug release
Tests for drug content
Weight variation- asseses drug content uniformity
Drug content uniformity- uniform active ingredient
Tests for drug release
Disintegration test- complete disintegration (no palpable core), and basket rack assembly.
*** Note fluids and disintegration times can vary according to drug monograph.
Sublingual NTGs must disintegrate in under _ minutes.
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